Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 44

  1. Cat.No. Product Name Information/Activity
  2. BCC3863 Telmisattan Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM. Telmisattan chemical structure
  3. BCC5017 Valsartan Valsartan (CGP-48933) is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure. Valsartan chemical structure
  4. BCC5734 ZD 7155 hydrochloride ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist. ZD 7155 hydrochloride chemical structure
  5. BCC6051 Novokinin 358738-77-9 Novokinin chemical structure
  6. BCC5010 PD123319 PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. PD123319 chemical structure
  7. BCC5921 CGP 42112 CGP-42112(CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist. CGP 42112 chemical structure
  8. BCC6963 BQ-123 BQ-123 is a selective endothelin A receptors (ETAR) antagonist with an IC50 value of 7.3 nM and a Ki vaule of 25 nM. BQ-123 chemical structure
  9. BCC7523 CI 1020 162256-50-0 CI 1020 chemical structure
  10. BCC5733 FR 139317 142375-60-8 FR 139317 chemical structure

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