Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 61

  1. Cat.No. Product Name Information/Activity
  2. BCC7718 Org 12962 hydrochloride 210821-63-9 Org 12962 hydrochloride chemical structure
  3. BCC7196 Ro 60-0175 fumarate 169675-09-6 Ro 60-0175 fumarate chemical structure
  4. BCC6849 SCH 23390 hydrochloride SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM. SCH 23390 hydrochloride chemical structure
  5. BCC7179 WAY 161503 hydrochloride 276695-22-8 WAY 161503 hydrochloride chemical structure
  6. BCC7271 WAY 629 hydrochloride 57756-44-2 WAY 629 hydrochloride chemical structure
  7. BCC5949 SB 242084 1215566-78-1 SB 242084 chemical structure
  8. BCC6035 SB 243213 dihydrochloride SB 243213 hydrochloride is an orally active, selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders. SB 243213 dihydrochloride chemical structure

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