Hypertension Research
Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.
Hypertension Research Products Targets
- Adenosine A2B Receptor (7)
- Adenosine A2A Receptor (11)
- Lipoxygenase (8)
- Leukotriene and Related Receptor (13)
- Bradykinin Receptor (12)
- Others (10)
- Cyclooxygenase (24)
- Apelin Receptor (5)
- 5-HT1F Receptor (2)
- 5-HT1E Receptor (1)
- 5-HT1D Receptor (13)
- 5-HT1B Receptor (20)
- 5-HT1A Receptor (25)
- 5-HT2C Receptor (23)
- 5-HT2B Receptor (12)
- 5-HT2A Receptor (25)
- Natriuretic Peptide Receptor (4)
- Mineralocorticoid Receptor (7)
- Angiotensin-Converting Enzyme (8)
- 5-HT7 Receptor (11)
- 5-HT6 Receptor (14)
- 5-ht5 Receptor (2)
- 5-HT4 Receptor (17)
- Histamine H4 Receptor (12)
- Histamine H3 Receptor (22)
- Histamine H2 Receptor (10)
- Histamine H1 Receptor (17)
- Adenosine A3 Receptor (8)
- Adenosine A1 Receptor (12)
- Calcitonin and Related Receptor (10)
- VIP Receptor (7)
- Vasopressin Receptor (6)
- NO donors and precursors (9)
- nNOS (5)
- iNOS (11)
- eNOS (1)
- Urotensin-II Receptor (8)
- ETB Receptor (6)
- ETA Receptor (5)
- Angiotensin AT2 Receptor (3)
- Angiotensin AT1 Receptor (9)
- M5 Receptor (2)
- M4 Receptor (3)
- M3 Receptor (4)
- Purinergic (P2Y) Receptor (31)
- M2 Receptor (5)
- M1 Receptor (8)
- Neuromedin U (2)
- NKCC (2)
- Adrenergic α2 Receptor (33)
- Adrenergic α1 Receptor (22)
- Adrenergic β3 Receptor (12)
- Adrenergic β2 Receptor (6)
- Adrenergic β1 Receptor (7)
- Protease-Activated Receptor (23)
- Prostanoid Receptor (24)
- Sphingosine-1-Phosphate Receptor (13)
- Phosphodiesterase (34)
Products for Hypertension Research - Page 61
- Cat.No. Product Name Information/Activity
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BCC7718
Org 12962 hydrochloride
210821-63-9
-
BCC7196
Ro 60-0175 fumarate
169675-09-6
-
BCC6849
SCH 23390 hydrochloride
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM.
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BCC7179
WAY 161503 hydrochloride
276695-22-8
-
BCC7271
WAY 629 hydrochloride
57756-44-2
-
BCC5949
SB 242084
1215566-78-1
-
BCC6035
SB 243213 dihydrochloride
SB 243213 hydrochloride is an orally active, selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders.


