Hypertension Research
Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.
Hypertension Research Products Targets
- Adenosine A2B Receptor (7)
- Adenosine A2A Receptor (11)
- Lipoxygenase (8)
- Leukotriene and Related Receptor (13)
- Bradykinin Receptor (12)
- Others (10)
- Cyclooxygenase (24)
- Apelin Receptor (5)
- 5-HT1F Receptor (2)
- 5-HT1E Receptor (1)
- 5-HT1D Receptor (13)
- 5-HT1B Receptor (20)
- 5-HT1A Receptor (25)
- 5-HT2C Receptor (23)
- 5-HT2B Receptor (12)
- 5-HT2A Receptor (25)
- Natriuretic Peptide Receptor (4)
- Mineralocorticoid Receptor (7)
- Angiotensin-Converting Enzyme (8)
- 5-HT7 Receptor (11)
- 5-HT6 Receptor (14)
- 5-ht5 Receptor (2)
- 5-HT4 Receptor (17)
- Histamine H4 Receptor (12)
- Histamine H3 Receptor (22)
- Histamine H2 Receptor (10)
- Histamine H1 Receptor (17)
- Adenosine A3 Receptor (8)
- Adenosine A1 Receptor (12)
- Calcitonin and Related Receptor (10)
- VIP Receptor (7)
- Vasopressin Receptor (6)
- NO donors and precursors (9)
- nNOS (5)
- iNOS (11)
- eNOS (1)
- Urotensin-II Receptor (8)
- ETB Receptor (6)
- ETA Receptor (5)
- Angiotensin AT2 Receptor (3)
- Angiotensin AT1 Receptor (9)
- M5 Receptor (2)
- M4 Receptor (3)
- M3 Receptor (4)
- Purinergic (P2Y) Receptor (31)
- M2 Receptor (5)
- M1 Receptor (8)
- Neuromedin U (2)
- NKCC (2)
- Adrenergic α2 Receptor (33)
- Adrenergic α1 Receptor (22)
- Adrenergic β3 Receptor (12)
- Adrenergic β2 Receptor (6)
- Adrenergic β1 Receptor (7)
- Protease-Activated Receptor (23)
- Prostanoid Receptor (24)
- Sphingosine-1-Phosphate Receptor (13)
- Phosphodiesterase (34)
Products for Hypertension Research - Page 42
- Cat.No. Product Name Information/Activity
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BCC1920
Salmeterol xinafoate
Salmeterol xinafoate is a long-acting beta-2 adrenergic receptor (β2AR) agonist, with Ki of 1.5 nM for WT β2AR, and used for asthma treatment.
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BCC6911
Zinterol hydrochloride
Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM.
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BCC4029
ICI 118,551 hydrochloride
ICI 118,551 (hydrochloride) is a highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
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BCC6860
BRL 37344, sodium salt
BRL 37344 sodium (BRL 37344A) is a specific β3-adrenergic receptor agonist. BRL 37344 sodium treatment significantly lowers the body weight of obese mice.
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BCC6949
CGP 12177 hydrochloride
64208-32-8
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BCC7091
CL 316243 disodium salt
151126-84-0
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BCC5688
ICI 215,001 hydrochloride
140850-02-8
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BCC7282
L-755,507
L755507 is a potent, selective agonist of β3-AR with an IC50 of 35 nM.
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BCC6881
Pindolol
Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM).
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BCC7833
SR 58611A hydrochloride
Amibegron hydrochloride is a selective β3-adrenoceptor agonist, with an EC50 of 3.5 nM for β-adrenoceptor in rat colon; Amibegron hydrochloride has anxiolytic and antidepressant activity.


