Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 36

  1. Cat.No. Product Name Information/Activity
  2. BCC4335 Phenylephrine HCl (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively. Phenylephrine HCl chemical structure
  3. BCC2494 Alfuzosin HCl Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH). Alfuzosin HCl chemical structure
  4. BCC5063 BMY 7378 5-HT<sub>1A</sub> partial agonist,BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3. BMY 7378 chemical structure
  5. BCC4324 Carvedilol Carvedilol (BM 14190) is a non-selective β/α-1 blocker. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome. Carvedilol chemical structure
  6. BCC1257 Doxazosin Mesylate Doxazosin mesylate (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. Doxazosin Mesylate chemical structure
  7. BCC6683 HEAT hydrochloride 30007-39-7 HEAT hydrochloride chemical structure
  8. BCC6688 Ifenprodil hemitartrate 23210-56-2 Ifenprodil hemitartrate chemical structure
  9. BCC6741 2-MPMDQ 149847-77-8 2-MPMDQ chemical structure
  10. BCC6947 (S)-(+)-Niguldipine hydrochloride 113145-69-0 (S)-(+)-Niguldipine hydrochloride chemical structure
  11. BCC6726 2-PMDQ 139047-55-5 2-PMDQ chemical structure

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