Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 34

  1. Cat.No. Product Name Information/Activity
  2. BCC7372 SCH 442416 316173-57-6 SCH 442416 chemical structure
  3. BCC7306 SCH 58261 SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively. SCH 58261 chemical structure
  4. BCC6165 TC-G 1004 1061747-72-5 TC-G 1004 chemical structure
  5. BCC6902 ZM 241385 ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM. ZM 241385 chemical structure
  6. BCC6197 BAY 60-6583 BAY 60-6583 is a potent and high-affinity agonist of adenosine A2B receptor (EC50 = 3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with Ki values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model. BAY 60-6583 chemical structure
  7. BCC7120 MRS 1706 MRS-1706 is a potent and selective adenosine A2B receptor inverse agonist. MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1 and A3 receptors respectively. MRS 1706 chemical structure
  8. BCC7473 MRS 1754 MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats. MRS 1754 chemical structure
  9. BCC7237 PSB 1115 152529-79-8 PSB 1115 chemical structure
  10. BCC7598 PSB 603 1092351-10-4 PSB 603 chemical structure
  11. BCC6938 2-Cl-IB-MECA 2-Cl-IB-MECA is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively. 2-Cl-IB-MECA chemical structure

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