Ischemia-Reperfusion Injury Research
Ischemia/Reperfusion (I/R) injury is defined as the cellular damage that results from a period of ischemia that is followed by the reestablishment of the blood supply to the infarcted tissue.Myocardial ischemia, also known as cardiac ischemia, is defined as the deprivation of oxygen and nutrients to the heart. This phenomenon occurs during a myocardial infarction, when an occlusive thrombus within a coronary artery prevents blood supply to the myocardium, but can also occur during cardiac surgery as a result of pharmacological intervention to temporarily stop the heart. Reperfusion restores blood supply to ischemic tissue, but this is paradoxically associated with further tissue damage.
Ischemia-Reperfusion Injury Research Products Targets
- Adenosine A2B Receptor (7)
- Adenosine A2A Receptor (11)
- Oxidative Phosphorylation (6)
- NHE (3)
- p53 (20)
- Inhibitor of Apoptosis (3)
- Caspase (9)
- Bcl-2 Family (13)
- Apoptosis Inducing (36)
- 14.3.3 Protein (1)
- Voltage-gated Sodium (NaV) Channel (30)
- Voltage-gated Potassium (KV) Channel (38)
- Others (7)
- Calcium-Sensing Receptor (4)
- Calcium Binding Protein Modulator (18)
- Epithelial Sodium Channel (3)
- Calpain (7)
- Adenosine A3 Receptor (8)
- Adenosine A1 Receptor (12)
- ASK1 (2)
- Acid-Sensing Ion Channel (3)
- Calcium-Activated Potassium (KCa) Channel (19)
- Calcium-Sensitive Protease Modulator (12)
- Inward Rectifier Potassium (Kir) Channel (21)
- NCX (5)
- Mitochondrial Permeability Transition Pore (3)
- Mitochondrial Calcium Uniporter (1)
- Ca2+-ATPase (7)
Products for Ischemia-Reperfusion Injury Research - Page 25
- Cat.No. Product Name Information/Activity
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BCC6054
Neuropeptide SF (mouse, rat)
230960-31-3
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BCC6294
APETx2
713544-47-9
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BCC1451
Capsazepine
Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC50 of 562 nM.
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BCC7673
Phenamil
1161-94-0
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BCC7515
Veratridine
Veratridine (3-Veratroylveracevine), a alkaloid derived from plants in the family Liliaceae, is a sodium channel agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM.
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BCC5075
A-803467
A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.
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BCC7898
A 887826
A-887826 is a potent, selective, oral bioavailable and voltage-dependent Na(v)1.8 sodium channel blocker with an IC50 of 11 nM . A-887826 attenuates neuropathic tactile allodynia in vivo.
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BCC5067
Ambroxol HCl
Na<sup>+</sup> channel blocker,AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
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BCC4378
Carbamazepine
Carbamazepine, a sodium channel blocker, is an anticonvulsant drug.
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BCC7439
Co 102862
181144-66-1
