Alzheimer's Disease Research

Alzheimer's disease (AD), the most common type of dementia, is an irreversible and progressive neurodegenerative disorder causing cognitive and functional impairment. It is characterized by formation of protein aggregates and progressive loss of neurons in the central nervous system (CNS). The symptoms of AD include short-term memory loss, confusion, irritability, aggression and mood swings, progressing to long-term memory deficit, withdrawal from social interactions and subsequently a loss in higher central functioning.

Alzheimer's Disease Research Products Targets

Products for Alzheimer's Disease Research - Page 29

  1. Cat.No. Product Name Information/Activity
  2. BCC6151 CMPDA CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor. CMPDA chemical structure
  3. BCC7532 CX 546 CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent. CX 546 chemical structure
  4. BCC6759 Cyclothiazide 2259-96-3 Cyclothiazide chemical structure
  5. BCC5951 PEPA PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity. PEPA chemical structure
  6. BCC6322 PF 4778574 PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells. PF 4778574 chemical structure
  7. BCC6081 S 18986 S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests. S 18986 chemical structure
  8. BCC4219 Aniracetam Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR. Aniracetam chemical structure
  9. BCC6974 IDRA 21 22503-72-6 IDRA 21 chemical structure
  10. BCC5787 pep2-AVKI 1315378-69-8 pep2-AVKI chemical structure
  11. BCC5786 pep2-EVKI 1315378-67-6 pep2-EVKI chemical structure

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