Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 43

  1. Cat.No. Product Name Information/Activity
  2. BCC7025 Nafadotride 149649-22-9 Nafadotride chemical structure
  3. BCC7435 NGB 2904 189061-11-8 NGB 2904 chemical structure
  4. BCC7801 PG 01037 dihydrochloride 675599-62-9 PG 01037 dihydrochloride chemical structure
  5. BCC7664 PNU 177864 hydrochloride 250266-51-4 PNU 177864 hydrochloride chemical structure
  6. BCC7887 SB 277011A dihydrochloride SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively. SB 277011A dihydrochloride chemical structure
  7. BCC7029 U 99194 maleate 234757-41-6 U 99194 maleate chemical structure
  8. BCC6224 A 412997 dihydrochloride Selective D<sub>4</sub> agonist A 412997 dihydrochloride chemical structure
  9. BCC7293 ABT 724 trihydrochloride ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile. ABT 724 trihydrochloride chemical structure
  10. BCC6919 PD 168077 maleate PD-168077 maleate is a selective dopamine D4 receptor agonist, with a Ki of 9 nM. PD 168077 maleate chemical structure
  11. BCC7330 Ro 10-5824 dihydrochloride Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM. Ro 10-5824 dihydrochloride chemical structure

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