Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 44

  1. Cat.No. Product Name Information/Activity
  2. BCC2054 WAY-100635 maleate salt WAY-100635 maleate salt is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate salt has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate salt is also a potent dopamine D4 receptor agonist. WAY-100635 maleate salt chemical structure
  3. BCC7440 Fananserin Fananserin (RP 62203) is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist, with a Ki of 0.37 nM for the rat 5-HT2A receptor. Fananserin also is a selective dopamine D4 receptor antagonist, with a Ki of 2.93 nM for the human dopamine D4 receptor. Fananserin chemical structure
  4. BCC5696 L-741,742 hydrochloride 874882-93-6 L-741,742 hydrochloride chemical structure
  5. BCC5695 L-745,870 trihydrochloride 866021-03-6 L-745,870 trihydrochloride chemical structure
  6. BCC7702 PD 168568 dihydrochloride 210688-56-5 PD 168568 dihydrochloride chemical structure
  7. BCC7467 PNU 96415E 170856-41-4 PNU 96415E chemical structure
  8. BCC7879 Sonepiprazole 170858-33-0 Sonepiprazole chemical structure
  9. BCC7636 NGD 94-1 178928-68-2 NGD 94-1 chemical structure
  10. BCC5957 DPNI-caged-GABA Nitroindoline-caged GABA DPNI-caged-GABA chemical structure
  11. BCC6575 Isoguvacine hydrochloride Isoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride chemical structure

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