Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 47

  1. Cat.No. Product Name Information/Activity
  2. BCC5521 Emapunil Emapunil(AC-5216;XBD-173) is a translocator protein [TSPO (18 kDa)] ligand. Emapunil chemical structure
  3. BCC7711 Bretazenil 84379-13-5 Bretazenil chemical structure
  4. BCC6635 β-CCB 84454-35-3 β-CCB chemical structure
  5. BCC7162 CL 218872 66548-69-4 CL 218872 chemical structure
  6. BCC6671 Dihydroergotoxine mesylate Dihydroergotoxine mesylate is a complex of closely related alkaloid salts; Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. Dihydroergotoxine mesylate chemical structure
  7. BCC7560 DMCM hydrochloride DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 receptors, respectively. DMCM hydrochloride chemical structure
  8. BCC6694 FG 7142 FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. FG 7142 chemical structure
  9. BCC6738 FGIN-1-27 142720-24-9 FGIN-1-27 chemical structure
  10. BCC6739 FGIN-1-43 145040-29-5 FGIN-1-43 chemical structure
  11. BCC1259 Flumazenil Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses. Flumazenil chemical structure

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