Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 50

  1. Cat.No. Product Name Information/Activity
  2. BCC7984 MaxiPost Flindokalner (BMS-204352) is a potassium channel modulator. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is also a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner shows a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM), and acts as a negative modulator of GABAA receptors. Flindokalner shows anxiolytic efficacy in vivo. MaxiPost chemical structure
  3. BCC6167 Ocinaplon 96604-21-6 Ocinaplon chemical structure
  4. BCC7470 Org 20599 156685-94-8 Org 20599 chemical structure
  5. BCC7452 17-PA 694438-95-4 17-PA chemical structure
  6. BCC7736 Pregnanolone 128-20-1 Pregnanolone chemical structure
  7. BCC4930 Primidone Primidone is an anticonvulsant of the pyrimidinedione class. Primidone chemical structure
  8. BCC7095 SB 205384 GABA<sub>A</sub> receptor modulator; slows current decay SB 205384 chemical structure
  9. BCC2314 Topiramate Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase. Topiramate chemical structure
  10. BCC7115 Tracazolate hydrochloride 1135210-68-2 Tracazolate hydrochloride chemical structure
  11. BCC7466 U 89843A 157013-85-9 U 89843A chemical structure

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