Schizophrenia Research

Schizophrenia is a chronic, debilitating mental disorder affecting 1-2% of the global population. Symptoms are split into two types; 'positive' symptoms, including delusions and hallucinations, and 'negative' symptoms, including anhedonia and lack of motivation. Studies suggest that genetics, early environment, neurobiology, psychological and social processes are important contributory factors; some recreational and prescription drugs appear to cause or worsen symptoms. Several neurobiological alterations in brain structure, physiology and neurochemistry have been documented, along with an ever-increasing list of susceptibility genes.

Schizophrenia Research Products Targets

Products for Schizophrenia Research - Page 69

  1. Cat.No. Product Name Information/Activity
  2. BCC7615 VU 0155041 1093757-42-6 VU 0155041 chemical structure
  3. BCC7642 VU 0155041 sodium salt 1259372-69-4 VU 0155041 sodium salt chemical structure
  4. BCC7616 Z-Cyclopentyl-AP4 103439-17-4 Z-Cyclopentyl-AP4 chemical structure
  5. BCC6872 CPPG CPPG ((RS)-CPPG) is a potent group II/III mGlu receptor antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors. CPPG chemical structure
  6. BCC7528 MMPIP hydrochloride 479077-02-6 MMPIP hydrochloride chemical structure
  7. BCC6818 MPPG 169209-65-8 MPPG chemical structure
  8. BCC7033 UBP1112 339526-74-8 UBP1112 chemical structure
  9. BCC6150 TC-N 22A 1314140-00-5 TC-N 22A chemical structure
  10. BCC7901 TCN 238 TCN238 is a positive allosteric mGlu4 receptor modulator with an EC50 of 1 μM. TCN 238 chemical structure
  11. BCC4596 VU 0361737 VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors. VU 0361737 chemical structure

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