Schizophrenia Research

Schizophrenia is a chronic, debilitating mental disorder affecting 1-2% of the global population. Symptoms are split into two types; 'positive' symptoms, including delusions and hallucinations, and 'negative' symptoms, including anhedonia and lack of motivation. Studies suggest that genetics, early environment, neurobiology, psychological and social processes are important contributory factors; some recreational and prescription drugs appear to cause or worsen symptoms. Several neurobiological alterations in brain structure, physiology and neurochemistry have been documented, along with an ever-increasing list of susceptibility genes.

Schizophrenia Research Products Targets

Products for Schizophrenia Research - Page 66

  1. Cat.No. Product Name Information/Activity
  2. BCC6609 L-CCG-l 117857-93-9 L-CCG-l chemical structure
  3. BCC5691 DCG IV DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1/5R=389/630 μM) and III receptors (IC50: mGlu4/6/7/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects. DCG IV chemical structure
  4. BCC7614 LY 354740 Eglumegad (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. LY 354740 chemical structure
  5. BCC7368 LY 379268 Highly selective group II mGlu agonist LY 379268 chemical structure
  6. BCC7623 (±)-LY 395756 852679-66-4 (±)-LY 395756 chemical structure
  7. BCC6758 MAP4 157381-42-5 MAP4 chemical structure
  8. BCC6925 (RS)-APICA 170847-18-4 (RS)-APICA chemical structure
  9. BCC6871 EGLU EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a potent and competitive mGluR-2 receptor antagonist. EGLU interacts with (lS,3S)-ACPD-sensitive site with a Kd value of 66 μM. EGLU is an antidepressant agent. EGLU chemical structure
  10. BCC1724 LY341495 LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively. LY341495 chemical structure
  11. BCC6819 MSPG 169209-64-7 MSPG chemical structure

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