Bromodomain
Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.
Products for Bromodomain
- Cat.No. Product Name Information
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BCC1132
Bromodomain Inhibitor, (+)-JQ1Potent, selective BET bromodomain inhibitor; cell permeable
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BCC1603
GSK 525768Ainactive stereoisomer of I-BET-762
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BCC1829
OTX-015BRD inhibitor
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BCC2023
UNC1215Chemical probe for the methyllysine (Kme)
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BCC2225
PFI-1 (PF-6405761)BET bromodomain inhibitor
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BCC2226
BromosporineBromodomain inhibitor,non-selective
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BCC2419
SGC-CBP30Inhibitor of CREBBP/EP300 bromodomain,potent
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BCC3603
(-)-JQ1BET bromodomain inhibitor
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BCC3997
UNC669L3MBTL antagonist,potent and selective
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BCC4037
MS436Potent and selective BRD4(1) inhibitor
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BCC4038
GSK1324726ABET proteins inhibitor
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BCC4099
CPI-203BET bromodomain inhibitor; arrests cell cycle at G1 phase
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BCC4474
I-BET-762BET inhibitor,highly potent
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BCC4475
RVX-208Potent BET bromodomain inhibitor
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BCC4476
I-BET151 (GSK1210151A)Selective BET inhibitor
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BCC5510
BET-BAY 002BET inhibitor, potent
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BCC5579
OF-1Selective BRPF1B and BRPF2 inhibitor
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BCC5597
GSK 5959Potent and selective BRPF1 inhibitor
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BCC5598
OXF BD 02Selective BRD4(1) inhibitor
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BCC6426
BET bromodomain inhibitorPotent and selective inhibitor for BRD4
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BCC6484
PFI 4Potent and selective BRPF1 bromodomain inhibitor
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BCC6498
GSK2801Selective BAZ2A and BAZ2B inhibitor