BCC7004
ARL 67156 trisodium salt
ARL67156 trisodium salt is an inhibitor of ecto-ATPase. ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively.
BCC1770
ML-7 hydrochloride
ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK (IC50=300 nM).
BCC4373
Golgicide A
Golgicide A is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF), GBF1. Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species.
BCC6050
Enterostatin
Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake.
BCC7454
POM 1
Sodium metatungstate (POM-1) is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively. Sodium metatungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition.
BCC1182
TAK-438
Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3.
BCC5604
ML 240
ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 value of 100 nM.
BCC3856
Sodium Orthovanadate
Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.
BCC6981
Cyclopiazonic acid
Cyclopiazonic acid (CPA), a neurotoxic secondary metabolite (SM) made by A. flavus, is a nanomolar inhibitor of endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA) and a potent inducer of cell death in plants.
BCC2253
Tipifarnib (Zarnestra)
Tipifarnib (R115777; IND 58359) is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib (R115777; IND 58359) binds to and inhibits farnesyltransferase (FTase) with IC50 of 0.6 nM.
BCC4387
Brefeldin A
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A is a CRISPR/Cas9 activator. Brefeldin A inhibits HSV-1 and has anti-cancer activity.
BCC1660
Istaroxime
Istaroxime (PST2744) is a potent inhibitor of Na+,K+-ATPase with IC50 of 0.11 μM.
BCN5359
Digoxin
Digoxin is a potent inhibitor of Na+/K+-ATPase, has the potential for arrhythmia and heart failure treatment.
BCC5106
BTB06584
BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase.
BCC1088
Dynasore
Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM.
BCC1661
Istaroxime hydrochloride
Istaroxime hydrochloride is a potent inhibitor of <b>Na<sup>+</sup>,K<sup>+</sup>-ATPase</b> with <b>IC<sub>50</sub></b> of 0.11 μM.
BCC4372
Ciclopirox ethanolamine
Ciclopirox olamine is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses.
BCC7978
Paprotrain
Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.
BCC7235
Paxilline
Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5 μM and 50 μM for differing isoforms. Paxilline possesses significant anticonvulsant activity.
BCC2530
Oligomycin A
Oligomycin A, created by Streptomyces, acts as a mitochondrial F0F1-ATPase inhibitor, with a Ki of 1 μM; Oligomycin A shows anti-fungal activity.
BCC6952
Thapsigargin
Thapsigargin is an inhibitor of microsomal Ca2+-ATPase. Thapsigargin is a well characterized Endoplasmic Reticulum (ER) stress inducing agent.
BCC7760
K858
K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM.
BCC7154
SCH 28080
SCH28080 inhibits gastric H+/K+-ATPase by K+-competitive binding, with an IC50 value of 20 nM in rabbit microsomal membranes. Antisecretory and cytoprotective activities.
BCC1301
20-HETE
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor. 20-HETE is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE constricts smooth muscles, stimulates smooth muscle proliferation and migration. 20-HETE increases NADPH oxidase, ROS, and NF-κB activity. 20-HETE also inhibits endothelial NO synthase and inhibits apoptosis of pulmonary artery smooth muscle cells.
BCC4375
(-)-Blebbistatin
(-)-Blebbistatin is a selective inhibitor of the ATPase activity of non-muscle myosin II.
BCC3710
Omecamtiv mecarbil
Omecamtiv mecarbil is a selective cardiac myosin activator.
