Products with Cytotoxic Bioactivity

Explore BioCrick products associated with Cytotoxic biological activity, including catalog numbers, product names and available bioactivity information.

Cat. No.	Product Name
BCN4547	Uncinatone
1. Uncinatone exhibits inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 12.50 uM. 2. Uncinatone shows inhibitory activity against complement system with 50% inhibitory concentrations (IC(50)) values of 87 uM. 3. Uncinatone demonstrates cytotoxic activities against the HL-60 tumour cell line (IC50 ＜ 20 uM). 4. Uncinatone exhibits moderate cytotoxicity, inhibits cell proliferation, and induces cell-cycle G(2)/M phase arrest.
BCN4580	1,3-Diacetylvilasinin
1. 1,3-Diacetylvilasinin shows marginal cytotoxicities against certain human tumor cell lines. 2. 1,3-Diacetylvilasinin shows antifeeding activity towards insects.
BCN4586	Piptocarphin A
1. Piptocarphin A shows strong cytotoxic activity against mouse lymphoid tumor cell line P388 with the IC(50) value of 0.77 microM .
BCN4602	6,8-Diprenylorobol
1. 6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected individuals. 2. 6,8-Diprenylorobol shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor (ER) antagonist. 3. 6,8-Diprenylorobol shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM). 4. 6,8-Diprenylorobol has antioxidant activity, it can reduce A2E photooxidation in a dose dependent manner. 5. 6,8-Diprenylorobol is evaluated against the AIDS-related opportunistic fungal pathogens, Candida albicans and Cryptococcus neoformans. 6. 6,8-Diprenylorobol can protect against 6-OHDA-induced neurotoxicity by enhancing the ubiquitin/proteasome-dependent degradation of α-synuclein and synphilin-1, suggesting that it may be a possible candidate for the treatment of neurodegenerative diseases.
BCN4638	Isodeoxyelephantopin
1. Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation . 2. Isodeoxyelephantopin enhances apoptosis and inhibit invasion and osteoclastogenesis by inhibiting NF-kappaB activation and NF-kappaB-regulated gene expression.

Cytotoxic Bioactivity Products