Products with Cytotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4314 | Lupalbigenin |
| 1. Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins. 2. Lupalbigenin, laburnetin , and isolupalbigenin show promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM). | |
| BCN4318 | Camptothecin |
| Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM; it is a novel alkaloidal leukemia and tumor inhibitor, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand breaks in chromosomal DNA. Camptothecin and its analogs reduce amyloid-β production and amyloid-β42-induced IL-1β production. | |
| BCN4322 | Garcinone C |
| 1. Garcinone C is the most potent inhibitor of AChE. 2. Garcinone C is the most active compound against both of pathogenic (MIC =100 μg/ml) and non-pathogenic leptospira (MIC = 200 μg/ml). 3. Garcinone C exhibits either significant or moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro. | |
| BCN4343 | Schinifoline |
| Schinifoline has cytotoxic activity, it also shows in vitro radiosensitising, cell cycle and apoptotic-inducing effects. | |
| BCN4399 | Norviburtinal |
| 1. Norviburtinal possesses novel angiogenesis effect. 2. Norviburtinal and isopinnatal show in vitro cytotoxicity against cancer cell lines. 3. Norviburtinal has little selectivity for melanoma cell lines whilst isopinnatal also shows some cytotoxic activity. | |
