Products with Cytotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3972 | Guajadial B |
| 1. Guajadial B shows cytotoxicities against five human cancer cell lines, it is the most effective having an IC50 value of 150 nM toward A549 cells. 2. Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. | |
| BCN3978 | Isoerysenegalensein E |
| 1. Isoerysenegalensein E shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway, which is triggered by mitochondrial dysfunction. 2. Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. | |
| BCN3990 | 3'-Methylflavokawin |
| 1. 3'-Methylflavokawin shows cytotoxicity against HeLa cells, the IC 50 value comparable to xanthohumol (8.2-19.2 microM). | |
| BCN4043 | Pellitorine |
| 1. Pellitorine shows strong cytotoxic activities against HL60 and MCT-7 cell lines. 2. Pellitorine can suppress expression of inducible NO synthase and cyclooxygenase-2. 3. Pellitorine shows antiprotozoal activity against Plasmodium falciparum (IC50 = 3.3 ug/mL). 4. Pellitorine is a potential larvicide with a specific target site and a lead molecule for the control of mosquito populations. 5. Pellitorine shows potent antiplatelet aggregation activity. | |
| BCN4087 | Kaempferol 3,7,4'-trimethylether |
| Kaempferol 3,7,4'-trimethylether shows selective cyctoxic activities against the nine tested cancer cell lines. | |
