Natural Products from Corydalis yanhusuo
Natural Products Isolated from Corydalis yanhusuo
BioCrick provides high-purity natural products and bioactive compounds isolated and purified from natural sources for scientific research.
- Natural product compounds selected from diverse chemical and biological sources.
- Broad structural diversity and coverage of biological activities.
- Product activity information can be supported by published literature, patents and research reports.
- Natural products can be selected according to source, target, activity and disease research interests.
- Compounds should be stored according to the product specifications after receipt.
Natural Products from Corydalis yanhusuo
16 natural product s associated with Corydalis yanhusuo
| Catalog No. | Product Name | CAS Number | COA |
|---|---|---|---|
| BCN2723 |
(-)-Isocorypalmine
|
483-34-1 | COA |
| BCN4546 |
4-Hydroxybenzoic acid
|
99-96-7 | COA |
| BCC5325 |
9-Hydroxycalabaxanthone hydrate
|
483-14-7 | COA |
| BCN9043 |
Allocryptopine
|
485-91-6 | COA |
| BCN2286 |
Coptisine sulfate
|
1198398-71-8 | COA |
| BCN2342 |
Corydaline
|
518-69-4 | COA |
| BCN2334 |
D-Tetrahydropalmatine
|
3520-14-7 | COA |
| BCN2474 |
Dehydrocorydalin
|
30045-16-0 | COA |
| BCN2273 |
Dihydrochelerythrine
|
6880-91-7 | COA |
| BCC8952 |
Docosanoic acid
|
112-85-6 | COA |
| BCN5989 |
Fumaric acid
|
110-17-8 | COA |
| BCN5285 |
Palmatine
|
3486-67-7 | COA |
| BCN6165 |
Protopine
|
130-86-9 | COA |
| BCN2648 |
Tetrahydroberberine
|
522-97-4 | COA |
| BCN6310 |
Tetrahydropalmatine
|
2934-97-6 | COA |
| BCN6105 |
Vanillic acid
|
121-34-6 | COA |
References
Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined with liquid chromatography-mass spectrometry.[Pubmed: 29866504]
In order to develop a direct and reliable method for discovering lead compounds from traditional Chinese medicines (TCMs), a comparative online ligand fishing platform was developed using immobilized capillary enzyme reactors (ICERs) in combination with liquid chromatography-mass spectrometry (LC-MS). Methacrylate-based monolithic capillaries (400 μm I.D. × 10 cm) containing epoxy reactive groups were used as support to immobilize the target enzyme acetylcholinesterase (AChE). The activity and kinetic parameters of the AChE-ICER were investigated using micro-LC-UV. Subsequently, ligand fishing and identification from mixtures was carried out using the complete AChE-ICER-LC-MS platform. For efficient distinction of true actives from false positives, highly automated comparative analyses were run alternatingly using AChE-ICERs and negative control-ICERs, both online installed in the system. After washing unbound compounds to the waste, bound ligands were eluted from the AChE-ICER to a trapping loop using a denaturing solution. The trapped ligands were further separated and identified using LC-MS. Non-specific binding to the monolith support or non-functional sites of the immobilized enzyme was investigated by exposing analytes to the negative control-ICER. The specificity of the proposed approach was verified by analyzing a known AChE inhibitor in the presence of an inactive compound. The platform was applied to screen for AChE inhibitors in extracts of Corydalis yanhusuo. Eight compounds (columbamine, jatrorrhizine, coptisine, palmatine, berberine, dehydrocorydaline, tetrahydropalmatine and corydaline) with AChE binding affinity were detected and identified, and their AChE inhibitory activities were further verified by an in vitro enzymatic inhibition assay. Experimental results show that the proposed comparative online ligand fishing platform is suitable for rapid screening and mass-selective detection of AChE inhibitors in complex mixtures.
Development and Validation of a HPLC-ESI-MS/MS Method for Simultaneous Quantification of Fourteen Alkaloids in Mouse Plasma after Oral Administration of the Extract of Corydalis yanhusuo Tuber: Application to Pharmacokinetic Study.[Pubmed: 29561801]
None
Metabolic profiles of corydaline in rats by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.[Pubmed: 29235899]
1. Corydaline, an isoquinoline alkaloid obtained from the rhizomes of Corydalis yanhusuo, exhibits anti-acetylcholinesterase, anti-angiogenic, anti-allergic and gastric-emptying activities. In this study, a rapid and reliable ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) method was developed and employed for the comprehensive study of the metabolites of corydaline in rats. 2. Altogether, 43 metabolites were identified in the plasma (11), bile (9), urine (34) and feces (21) of rats after oral administration of corydaline at a dose of 4.5mg/kg. 3. It was demonstrated that demethylation, hydroxylation, sulfation and glucuronidation were the major metabolic transformation pathways. Among these, two metabolites were identified as tetrahydropalmatine and isocorybulbine, and 33 phase I and phase II products were inferred to be new metabolites arising from the in vivo metabolism of corydaline. 4. Importantly, this research provides scientific and reliable support for full understanding of the metabolic profiles of corydaline and the results could help to elucidate its safety and efficacy.