Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN2665 | Acetylshikonin |
| Acetylshikonin has anti-cancer and anti-inflammatory activity, it is a novel general P450 inhibitor with IC50 values of 1.4-4.0 μM for all tested P450s. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC50 of over 20 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and angiogenic factors. Certain shikonin derivatives(such as Acetylshikonin) act as modulators of the Nur77-mediated apoptotic pathway. | |
| BCN2666 | N-acetylanonaine |
| 1. Anemonin, a naturally occurring selective iNOS inhibitor, it has potential anti-inflammatory effect. 2. Anemonin is a potent protective molecule for osteoarthritis, it delays osteoarthritis progression by suppressing ECM loss and chondrocyte hypertrophy partially by suppressing IL-1β/NF-κB pathway activation. 3. Anemonin can alleviate nerve injury after cerebral ischemia and reperfusion (i/r) in rats by improving antioxidant activities and inhibiting apoptosis pathway. 4. Anemonin inhibits melanin synthesis by inhibiting the transcription of the genes encoding MITF, TYR, TRP1, and TRP2. | |
| BCN2667 | Baldrinal |
| 1. Baldrinal shows selective cytotoxicity against metastatic prostate cancer (PC-3M) and colon cancer (HCT-8) cell lines. 2. Baldrinal, valtrate, and acevaltrate are the quality control compounds of Valeriana jatamansi Jones. | |
| BCN2668 | Cistanoside A |
| 1. Cistanoside A possesses protective activities on CCl4 induced hepatotoxicity in mice, which is involved with increasing free radicals clearing activities, alleviating lipid-overoxidation damage, and improving respiratory chain function in mitochondria. | |
| BCN2669 | Corydine |
| 1. Corydine shows antimicrobial activity. 2. Corydine shows antineoplastic activity. 3. Corydine is the adrenolytic and weak cholinergic agent. 4. Corydine shows irritant and respiratory stimulant and CNS depressant activities . 5. Injected intravenously in rabbits corydine produced an initial fall in blood pressure followed by a return to normal or above normal. | |
| BCN2670 | Corytuberine |
| 1. Corytuberine was inhibited only by naloxone and that of bulbocapnine preferentially by yohimbine. | |
| BCN2672 | 3-O-Acetyl-beta-boswellic acid |
| 3-O-Acetyl-beta-boswellic acid has antitumor activity, it inhibits synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner with IC50 values ranging from 0.6 to 7.1 microM. | |
| BCN1381 | 3-O-Acetyl-11-keto-beta-boswellic acid |
| 3-O-Acetyl-11-keto-beta-boswellic acid inhibits 5-lipoxygenase product formation with an IC(50) of 1.5 m muM. | |
