Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 897 - 904 of 9359 hot products
| Catalog No. | Product Name |
|---|---|
| BCC4547 | Grossamide K |
|
1. Grossamide K exerts a particularly strong anti-melanogenic activity on the cells without high cell toxicity.
|
|
| BCC4548 | JIB-04 |
|
Pan Jumonji histone demethylase inhibitor (IC50 values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). Exhibits negligible activity at PHD2 and TET1. Selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. Prolongs survival in a mouse model of breast cancer.
|
|
| BCC4553 | NVP-ADW742 |
|
ATP-competitive inhibitor of IGF1R (IC<sub>50</sub> in the range of 0.1-0.2 <span class='symbol'>μ</span>M). Also inhibits c-Kit kinase activity (IC<sub>50</sub> in the range of 3-5 <span class='symbol'>μ</span>M). Exhibits a synergistic effect with Imatinib, enhancing the sensitivity of multiple small cell lung cancer cell lines to the chemotherapeutics etoposide and carboplatin.
|
|
| BCC4554 | SC-514 |
|
Orally active, ATP-competitive IKK<span class='symbol'>β</span> inhibitor (IC<sub>50</sub> = 3 - 12 <span class='symbol'>μ</span>M) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Attenuates NF-<span class='symbol'>κ</span>B-induced gene expression of IL-6, IL-8 and COX-2 in synovial fibroblasts (IC<sub>50</sub> values are 20, 20 and 8 <span class='symbol'>μ</span>M respectively). Reduces iNOS induction and exhibits anti-inflammatory activity <em>in vivo</em>.
|
|
| BCC4556 | IMD 0354 |
|
Inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G0/G1 cell cycle arrest and apoptosis in HMC-1 and breast cancer cells.
|
|
| BCC4559 | SB743921 |
|
Potent kinesin spindle protein (KSP) inhibitor (Ki = 0.1 nM). Induces cell mitotic arrest and apoptosis in vitro. Inhibits the growth of a range of tumor cells in vitro, including colon (HCT 116), prostate (PC-3) and leukemia (K-562) cancer cell lines. Causes tumor regression in human tumor xenograft models in vivo, including colon (Colo205), lung (H69) and breast (MCF7) cancer cell xenografts.
|
|
| BCC4561 | Hexamethonium Bromide |
|
Nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.
|
|
| BCC4565 | Biperiden HCl |
|
Muscarinic receptor antagonist that displays some selectivity for the M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.
|
|