Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 841 - 848 of 9359 hot products
| Catalog No. | Product Name |
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| BCC4375 | (-)-Blebbistatin |
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Selective inhibitor of myosin II ATPase activity (IC<sub>50</sub> ~0.5 - 5 <span class='symbol'>μ</span>M); active enantiomer of (±)-blebbistatin. Inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
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| BCC4378 | Carbamazepine |
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Inhibitor of neuronal voltage-gated Na<sup>+</sup> channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl<sup>-</sup> currents in HEK 293 cells expressing the GABA<sub>A</sub> receptor <span class='symbol'>α</span>1<span class='symbol'>β</span>2<span class='symbol'>γ</span>2 subtype combination. Can induce autophagy by inhibiting inositol synthesis.
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| BCC4380 | Loperamide HCl |
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High affinity <span class='symbol'>μ</span>-opioid receptor agonist with peripheral selectivity (K<sub>i</sub> values are 2, 48 and 1156 nM for <span class='symbol'>μ</span>-, <span class='symbol'>δ</span>- and <span class='symbol'>κ</span>-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca<sup>2+</sup> channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca<sup>2+</sup> channels and at higher concentrations it reduces Ca<sup>2+</sup> flux through NMDA receptor operated channels.
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| BCC4382 | Tamoxifen Citrate |
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Estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo. Also high affinity agonist at the membrane estrogen receptor GPER. Tamoxifen (Cat.No. 6432) is also available.
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| BCC4385 | Azithromycin |
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Macrolide antibiotic. Inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram-positive and gram-negative organisms. Orally active with improved pharmacokinetics over erythromycin in mouse models.
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| BCC4386 | Temozolomide |
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DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC<sub>50</sub> = 5.0 <span class='symbol'>μ</span>M for cytotoxicity against mouse TLX5 lymphoma cells). Induces autophagy in malignant glioma cells. Exhibits enhanced activity when used in combination with CHC.
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| BCC4387 | Brefeldin A |
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Reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange. Can be used to induce autophagy in mammalian cells. Also enhances CRISPR-mediated homology-directed repair (HDR) efficiency ~2-fold when applied at 100 nM, in human induced pluripotent stem cells (iPSCs).
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| BCC4391 | GW5074 |
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Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm.
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