Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 785 - 792 of 9359 hot products
| Catalog No. | Product Name |
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| BCC4099 | CPI-203 |
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BET bromodomain inhibitor. Downregulates Myc expression, causes G<sub>1</sub> cell cycle arrest and attenuates cell proliferation in human pancreatic neuroendocrine tumors. Arrests the growth of T cell acute lymphoblastic leukemia cells <em>in vitro</em> (EC<sub>50</sub> = 91.2 nM). Also enhances the antitumor effect of rapamycin <em>in vitro</em> and attenuates rapamycin induced Akt activation. Orally bioavailable.
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| BCC4100 | PCI 29732 |
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Potent BTK inhibitor (IC50 = 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+ B cells.
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| BCC4104 | GlyH-101 |
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Reversible, voltage-dependent CFTR chloride channel blocker (K<sub>i</sub> = 4.3 <span class='symbol'>μ</span>M). Inhibits forskolin</a>-induced hyperpolarization in nasal potential differences and inhibits cholera toxin-induced intestinal fluid secretion in mice.
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| BCC4109 | Salicylic acid |
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1. Salicylic acid , a phenolic phytohormone, can alleviate the damaging effects of the triple stress by improving the antioxidant system, although these effects differed depending on characteristic of the hull of the grain.
2. Salicylic acid plays a key role in regulation of plant immune responses to different attackers. |
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| BCC4112 | Sumanirole maleate |
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High affinity D<sub>2</sub> receptor agonist (EC<sub>50</sub> values are between 17 and 75 nM in cell-based assays). Displays >200-fold selectivity for the D<sub>2</sub> receptor against other dopamine receptor subtypes (K<sub>i</sub> values are 9.0, 1940, >2190 and >7140 for D<sub>2</sub>, D<sub>3</sub>, D<sub>4</sub> and D<sub>1</sub> receptors respectively). Exhibits antiParkinsonian activity similar to ropinirole.
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| BCC4146 | Xanomeline oxalate |
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Functionally selective muscarinic M1 receptor agonist (EC50 values are 0.3, 5, 42, 52 and 92.5 nM at M1, M3, M5, M4 and M2 receptors respectively). Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M1; delayed wash-resistant partial agonist activity at M2; and delayed wash-resistant full agonist activity at M4. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia.
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| BCC4159 | Ro 25-6981 Maleate |
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Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC<sub>50 </sub>values are 0.009 and 52 <span class='symbol'>μ</span>M for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects <em>in vivo</em> and <em>in vitro</em>.
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| BCC4161 | MCOPPB trihydrochloride |
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High affinity NOP receptor agonist (pKi = 10.07 for the human NOP receptor). Exhibits anxiolytic effects with no effect on memory or locomotion. Regarded as one of the most potent, non-peptide NOP full agonists in vitro.
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