Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 745 - 752 of 9359 hot products
| Catalog No. | Product Name |
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| BCC3957 | TRAP-6 |
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Peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR<sub>1</sub>) that acts as a PAR<sub>1</sub> agonist. Stimulates platelet aggregation (EC<sub>50</sub> = 0.8 <span class='symbol'>μ</span>M), promotes intracellular Ca<sup>2+</sup> mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation <em>in vitro</em>.
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| BCC3958 | 2-Furoyl-LIGRLO-amide |
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Potent and selective PAR2 receptor agonist (pD2 = 7.0). Causes a dose-dependent relaxation of murine femoral arteries.
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| BCC3959 | SLIGKV-NH2 |
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Protease-activated receptor 2 (PAR<sub>2</sub>) agonist (K<sub>i</sub> = 9.64 <span class='symbol'>μ</span>M and IC<sub>50</sub> = 10.4 <span class='symbol'>μ</span>M). Corresponds to the tethered ligand exposed by trypsin cleavage of PAR-2. Control peptide VKGILS-NH<sub>2</sub> also available.
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| BCC3960 | 7-Hydroxy-2,3,4,5-tetrahydro-1H-benzofuro[2,3-c]azepin-1-one |
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Selective protein kinase D (PKD) inhibitor (IC<sub>50</sub> values are 0.182, 0.280, 0.227, >10, 15.3, 20.3, 40.5 and >50 <span class='symbol'>μ</span>M at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKII<span class='symbol'>α</span> and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion <em>in vitro</em>.
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| BCC3963 | NVP-BHG712 |
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Selective inhibitor of EphB4 kinase; exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Inhibits EphB4 autophosphorylation in transiently transfected HEK 293 cells. Also inhibits VEGF-induced angiogenesis in vivo; thought to inhibit EphB4 forward signaling. Orally active.
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| BCC3965 | Wnt-C59 |
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Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC<sub>50</sub> = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/<span class='symbol'>β</span>-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021. Cell permeable and orally bioavailable.
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| BCC3966 | VX-745 |
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Highly potent and selective p38<span class='symbol'>α</span> inhibitor (IC<sub>50</sub> = 10 nM). Also blocks TNF<span class='symbol'>α</span> production in LPS-stimulated HWB <em>in vitro</em> (IC<sub>50</sub> = 177 nM). Displays 1000-fold selectivity over closely related kinases, including ERK1, MK2 and JNK1-3.
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| BCC3967 | 1-O-galloyl-2-O-cinnamoyl-beta-d-glucose |
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Orally active, ATP-competitive inhibitor of p38α MAPK; also inhibits p38β (KD values are 3.7 and 17 nM respectively).
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