Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 729 - 736 of 9359 hot products
| Catalog No. | Product Name |
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| BCC3941 | SANT-1 |
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Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
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| BCC3942 | Cilengitide |
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Potent and selective inhibitor of integrins <span class='symbol'>α</span><sub>v</sub><span class='symbol'>β</span><sub>3</sub> and <span class='symbol'>α</span><sub>v</sub><span class='symbol'>β</span><sub>5</sub> (IC<sub>50</sub> values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.
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| BCC3943 | MNS |
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Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC<sub>50</sub> = 12.7 <span class='symbol'>μ</span>M for thrombin-induced platelet aggregation). Exhibits no effects on Ca<sup>2+</sup>-dependent enzymes, PKC or arachidonic acid metabolism.
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| BCC3944 | A 205804 |
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Selective inhibitor of E-selectin and ICAM-1 expression (IC<sub>50</sub> values are 20, 25 and > 1000 nM for TNF-<span class='symbol'>α</span>-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an <em>in vitro</em> flow experiment.
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| BCC3945 | BIO 1211 |
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Selective, high affinity <span class='symbol'>α</span><sub>4</sub><span class='symbol'>β</span><sub>1</sub> (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of <span class='symbol'>α</span><sub>4</sub><span class='symbol'>β</span><sub>1</sub> (K<sub>D</sub> = 70 pM; IC<sub>50</sub> = 0.004 <span class='symbol'>μ</span>M). Selective for <span class='symbol'>α</span><sub>4</sub><span class='symbol'>β</span><sub>1</sub> over a range of other integrins (IC<sub>50</sub> >100 <span class='symbol'>μ</span>M for <span class='symbol'>α</span><sub>1</sub><span class='symbol'>β</span><sub>1</sub>, <span class='symbol'>α</span><sub>5</sub><span class='symbol'>β</span><sub>1</sub> and <span class='symbol'>α</span><sub>6</sub><span class='symbol'>β</span><sub>1</sub>).
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| BCC3946 | A 286982 |
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Potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively).
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| BCC3947 | SLIGRL-NH2 |
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Agonist peptide derived from the N-terminus of protease-activated receptor-2 (PAR<sub>2</sub>). Activates PAR<sub>2</sub> (EC<sub>50</sub> ~ 5 <span class='symbol'>μ</span>M) and facilitates gastrointestinal transit in mice <em>in vivo</em>. Control peptide LRGILS-NH<sub>2</sub> also available.
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| BCC3948 | TFLLR-NH2 |
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Peptide derived from the protease-activated receptor-1 (PAR<sub>1</sub>) that acts as a PAR<sub>1</sub> selective agonist (EC<sub>50</sub> = 1.9 <span class='symbol'>μ</span>M). Stimulates PAR<sub>1</sub>-mediated plasma extravasation <em>in vivo</em>. Control Peptide RLLFT-NH<sub>2</sub> also available.
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