Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 689 - 696 of 9359 hot products
| Catalog No. | Product Name |
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| BCC3856 | Sodium Orthovanadate |
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Inhibitor of protein tyrosine phosphatases, alkaline phosphatases and ATPases. Suppresses p53-mediated apoptosis by transcription-dependent and -independent pathways.
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| BCC3863 | Telmisattan |
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Antagonist of the angiotensin II type 1 receptor (AT<sub>1</sub>) (K<sub>i</sub> = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPAR<span class='symbol'>γ</span> receptors; shown to improve insulin sensitivity in rodents receiving high fat diets.
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| BCC3866 | Terfenadine |
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Histamine H<sub>1</sub> receptor antagonist. Also blocks K<sub>V</sub>11.1 (hERG) and K<sub>ir</sub>6 (K<sub>ATP</sub>) channels (IC<sub>50</sub> values are 204 nM and 1.2 <span class='symbol'>μ</span>M respectively). Inhibits the delayed rectifier K<sup>+</sup> current (I<sub>Kr</sub>) in guinea pig ventricular myocytes (IC<sub>50</sub> = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic <em>in vivo</em>.
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| BCC3872 | Triciribine |
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Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3<span class='symbol'>β</span> and AFX. Induces apoptosis and growth arrest <em>in vitro</em>, preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
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| BCC3873 | Triflurdine (Viroptic) |
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Nucleoside analog; inhibitor of thymidylate synthase. Incorporation of the triphosphate form into DNA induces DNA fragmentation. Exhibits antitumor activity.
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| BCC3874 | Wortmannin |
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Potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC<sub>50</sub> = 2 - 4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC<sub>50</sub> = 5.8 nM).
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| BCC3875 | ZM336372 |
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Potent, selective inhibitor of c-Raf <em>in vitro</em> (IC<sub>50</sub> = 70 nM for inhibition of human c-Raf). Shows 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC<sub>50</sub> = 2 <span class='symbol'>μ</span>M). Selective over 17 other protein kinases including PKA, PKC, p42 MAPK, CDK1 and SAPK1/JNK (up to 50 <span class='symbol'>μ</span>M). Also available as part of the MAPK Cascade Inhibitor.
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| BCC3878 | LY335979 (Zosuquidar 3HCL) |
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High affinity P-glycoprotein (P-gp) inhibitor (K<sub>d</sub> = 79 nM). Restores doxorubicin sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol in a MDR human non-small cell lung carcinoma xenograft mouse model.
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