Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 633 - 640 of 9359 hot products
| Catalog No. | Product Name |
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| BCC3689 | AZD-5438 |
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Potent inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo.
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| BCC3690 | Verteporfin |
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YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC<sub>50</sub> = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties <em>in vitro</em>. Suppresses YAP-induced liver overgrowth in mice.
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| BCC3701 | NSC 74859 |
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Selectively inhibits STAT3 DNA-binding activity <em>in vitro</em> (IC<sub>50</sub> values are 86, 160, and >300 <span class='symbol'>μ</span>M for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). Blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 <em>in vitro</em> and arrests tumor growth in a murine xenograft model <em>in vivo</em>.
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| BCC3703 | Go 6976 |
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Potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.
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| BCC3704 | GF 109203X |
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Very potent and selective inhibitor of protein kinase C, selective for the <span class='symbol'>α</span> and <span class='symbol'>β</span>1 isoforms (IC<sub>50</sub> values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 <span class='symbol'>μ</span>M for <span class='symbol'>α</span>, <span class='symbol'>β</span>1, <span class='symbol'>δ</span>, <span class='symbol'>ε</span> and <span class='symbol'>ζ</span> isoforms respectively). Selective over MLCK, PKG and PKA (IC<sub>50</sub> values are 0.6, 4.6, and 33 <span class='symbol'>μ</span>M respectively). Potent antagonist at the 5-HT<sub>3</sub> receptor (K<sub>i</sub> = 29.5 nM). Anti-inflammatory <em>in vivo</em>.
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| BCC3705 | Go 6983 |
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Broad spectrum protein kinase C (PKC) inhibitor (IC<sub>50</sub> values are 7, 7, 6, 10, 60 and 20000 nM for PKC<span class='symbol'>α</span>, PKC<span class='symbol'>β</span>, PKC<span class='symbol'>γ</span>, PKC<span class='symbol'>δ</span>, PKC<span class='symbol'>ζ</span> and PKC<span class='symbol'>μ</span> respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).
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| BCC3706 | K-252c |
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Inhibitor of protein kinase C (IC<sub>50</sub> = 2.45 <span class='symbol'>μ</span>M) that displays ~ 10-fold selectivity over protein kinase A (IC<sub>50</sub> = 25.7 <span class='symbol'>μ</span>M). Also inhibits <span class='symbol'>β</span>-lactamase, malate dehydrogenase and chymotrypsin (IC<sub>50</sub> values are 8, 8 and 10 <span class='symbol'>μ</span>M respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC<sub>50</sub> values range from 0.13 - 0.32 <span class='symbol'>μ</span>M). Shows no activity against herpes simplex virus (HSV).
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| BCC3714 | 3-Methyladenine |
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Inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.
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