Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN2302 | Solasonine |
| Solasonine displays leishmanicidal activity against promastigote forms of L. amazonensis. | |
| BCN2303 | 10-Methoxycamptothecin |
| 10-Methoxycamptothecin possesses high anti-cancer activity. | |
| BCN2304 | Alisol B acetate |
| Alisol B acetate can induce Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to the apoptotic effect. Alisol B acetate exhibits an antiproliferative effect in SGC7901 cells by inducing apoptosis, apoptosis of SGC7901 cells involves mitochondria-caspase and PI3K/Akt dependent pathways. | |
| BCN2305 | Solamargine |
| Solamargine has potential anti-trypanosomal, and anti-cancer activities; interactions between the glycoalkaloids solasonine and solamargine have inhibition of fungal growth. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity. | |
| BCN2306 | Methysticin |
| 1. Methysticin and yangonin show in vitro hepatotoxicity on human hepatocytes (HepG2) . 2. Methysticin and 7,8-dihydroMethysticin contribute to CYP1A1 induction. 3. Methysticin is a potent NF-kappaB inhibitor in kava with minimum toxicity. 4. Methysticin possesses anticonvulsant and neuroprotective properties, possibly by interfering with frequency potentiation. | |
| BCN2307 | Ginkgolic acid C15:1 |
| Ginkgolic acid C15:1 has antibacterial, antiparasitic, and anti-cancer activities, it can suppress lung cancer invasion and migration through the inhibition of PI3K/Akt/mTOR signaling pathway. | |
| BCN2308 | Dihydroisotanshinone I |
| Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scavenging activity and inhibition of lipid peroxidation. | |
| BCN2309 | (+)-Catechin hydrate |
| (+)-Catechin hydrate has antioxidant activity and is effective in reducing oxidative stress. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. | |
