Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 593 - 600 of 9359 hot products
| Catalog No. | Product Name |
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| BCC3589 | AM 114 |
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Inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC<sub>50</sub> ~ 1 <span class='symbol'>μ</span>M). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC<sub>50</sub> = 1.49 <span class='symbol'>μ</span>M).
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| BCC3593 | HA14-1 |
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Cell-permeable inhibitor of Bcl-2 protein (IC<sub>50</sub> ~ 9 <span class='symbol'>μ</span>M); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells. Also binds to the antiapoptotic Blc-2 proteins Bcl-XL and Bcl-w.
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| BCC3597 | Romidepsin (FK228, depsipeptide) |
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Potent and selective inhibitor of class I histone deacetylases (HDACs) (IC<sub>50</sub> values are 36, 47, 510 and 14,000 nM for HDAC1, HDAC2, HDAC4 and HDAC6 respectively). Exhibits cytotoxicity against various human tumor cell lines; also exhibits antitumor activity against human tumor xenografts.
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| BCC3599 | Apicidin |
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Potent histone deacetylase (HDAC) inhibitor (IC50 = 0.7 nM in an enzyme activity assay). Antiangiogenic and anti-invasive; blocks proliferation of human stomach and breast cancer cells. Induces apoptosis and autophagy in human oral squamous carcinoma cells.
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| BCC3600 | PAC-1 |
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Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC<sub>50</sub> = 0.22 <span class='symbol'>μ</span>M). Also activates procaspase-7 in a less efficient manner (EC<sub>50</sub> = 4.5 <span class='symbol'>μ</span>M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC<sub>50</sub> values are 0.003 - 1.41 and 5.02 - 9.98 <span class='symbol'>μ</span>M respectively).
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| BCC3602 | KN-62 |
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Selective, cell-permeable inhibitor of CaM kinase II (IC<sub>50</sub> = 0.9 <span class='symbol'>μ</span>M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X<sub>7</sub> receptor (IC<sub>50</sub> = 15 nM).
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| BCC3603 | (-)-JQ1 |
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Inactive control for (+)-JQ1. Exhibits no significant interaction with BRD1-4 or a panel of other bromodomains.
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| BCC3605 | Trichostatin A (TSA) |
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Selective and potent inhibitor of histone deacetylase (Ki = 3.4 nM). Active in vivo. Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Activates autophagy.
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