Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 609 - 616 of 9359 hot products
| Catalog No. | Product Name |
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| BCC3631 | PP 2 (AG 1879) |
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Selective inhibitor of Src-family tyrosine kinases. Inhibits p56<sup>lck</sup> and p59<sup>fynT</sup> (IC<sub>50</sub> values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC<sub>50</sub> = 0.73 <span class='symbol'>μ</span>M). Negative control PP 3 also available.
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| BCC3632 | ICG 001 |
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Inhibitor of TCF/<span class='symbol'>β</span>-catenin-mediated transcription. Selectively inhibits <span class='symbol'>β</span>-catenin/CBP interaction; displays no effect on <span class='symbol'>β</span>-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.
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| BCC3635 | BX795 |
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Inhibitor of 3-phosphoinositide-dependent kinase 1 (PDPK1). Inhibits Akt phosphorylation at Thr308 in PC3 cells; also inhibits anchorage-independent growth of PC3 and MDA-MB-468 cells. Exhibits activity at other kinases, including TANK-binding kinase 1 (TBK1), Aurora B and I<span class='symbol'>κ</span>B kinase <span class='symbol'>ε</span> (IKK<span class='symbol'>ε</span>).
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| BCC3636 | 5-(3-Chlorophenyl)-N-[4-(morpholin-4-ylmethyl)phenyl]furan-2-carboxamide |
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Protein kinase D (PKD) inhibitor (IC<sub>50</sub> values are 0.6, 0.7 and 3.2 <span class='symbol'>μ</span>M for PKD2, PKD3 and PKD1 respectively). Cell permeable (EC<sub>50</sub> = 10 <span class='symbol'>μ</span>M for PKD1 inhibition). ATP-competitive.
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| BCC3641 | Purmorphamine |
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Smoothened (Smo) receptor agonist (EC<sub>50</sub> ~ 1 <span class='symbol'>μ</span>M). Induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.
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| BCC3642 | ML161 |
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Inhibitor of protease-activated receptor 1 (PAR<sub>1</sub>)-mediated platelet activation (IC<sub>50</sub> = 0.26 <span class='symbol'>μ</span>M for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.
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| BCC3644 | DMXAA (Vadimezan) |
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mSTING agonist; selective for mouse STING over human STING. Induces IFN-<span class='symbol'>β</span> and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral.
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| BCC3650 | SB 216763 |
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Potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC<sub>50</sub> = 34.3 nM for GSK-3<span class='symbol'>α</span>). Equally effective at inhibiting human GSK-3<span class='symbol'>α</span> and GSK-3<span class='symbol'>β</span>. Exhibits minimal activity against 24 other protein kinases (IC<sub>50</sub> >10 <span class='symbol'>μ</span>M). Stimulates glycogen synthesis in liver cells, and induces <span class='symbol'>β</span>-catenin-dependent gene transcription. Neuroprotective; also reduces pulmonary inflammation and fibrosis in a mouse model. Shown to maintain mouse embryonic stem cells in a pluripotent state.
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