Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 601 - 608 of 9359 hot products
| Catalog No. | Product Name |
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| BCC3606 | AICAR |
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Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.
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| BCC3607 | SR 11302 |
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Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects <em>in vivo</em>. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC<sub>50</sub> > 1 <span class='symbol'>μ</span>M for RAR<span class='symbol'>α</span>, RAR<span class='symbol'>β</span>, RAR<span class='symbol'>γ</span> and RXR<span class='symbol'>α</span>).
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| BCC3612 | Staurosporine |
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Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC<sub>50</sub> = 3 nM), protein kinase A (IC<sub>50</sub> = 7 nM), p<sup>60v-src</sup> tyrosine protein kinase (IC<sub>50</sub> = 6 nM) and CaM kinase II (IC<sub>50</sub> = 20 nM).
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| BCC3616 | P 22077 |
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Inhibitor of ubiquitin-specific protease (USP) 7 (EC<sub>50</sub> = 8.6 <span class='symbol'>μ</span>M); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin <em>in vitro</em>. Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) histone lysine acetyltransferase.
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| BCC3618 | DAPT (GSI-IX) |
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Inhibitor of <span class='symbol'>γ</span>-secretase; causes a reduction in A<span class='symbol'>β</span>40 and A<span class='symbol'>β</span>42 levels in human primary neuronal cultures (IC<sub>50</sub> values are 115 and 200 nM for total A<span class='symbol'>β</span> and A<span class='symbol'>β</span>42 respectively) and in brain extract, cerebrospinal fluid and plasma <em>in vivo</em>. Does not affect APP<span class='symbol'>α</span> and APP<span class='symbol'>β</span> levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes ESCs to commit to neuronal differentiation.
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| BCC3620 | Ritonavir |
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HIV-1 and HIV-2 protease inhibitor (EC<sub>50</sub> values are 0.022-0.13 and 0.16 <span class='symbol'>μ</span>M, respectively). Blocks the metabolism of protease inhibitors by liver enzyme cytochrome P450-3A4 (CYP3A4). Orally bioavailable.
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| BCC3627 | PR-619 |
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Broad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells.
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| BCC3630 | PP 1 |
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Potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl.
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