Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 641 - 648 of 9359 hot products
| Catalog No. | Product Name |
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| BCC3715 | A66 |
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Potent and selective PI 3-kinase p110<span class='symbol'>α</span> inhibitor (IC<sub>50</sub> = 32 nM). Exhibits >100-fold selectivity for p110<span class='symbol'>α</span> over other PI 3-kinase isoforms. Inhibits Akt signaling and tumor growth in SK-OV-3 xenografts in mice.
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| BCC3719 | Alendronate sodium |
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Osteoclast-mediated bone resorption inhibitor. Binds and blocks farnesyl diphosphate synthase (FPPS) in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS); causes macrophage apoptosis. Inhibits prenylation and sterol biosynthesis in purified osteoclasts.
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| BCC3723 | Argatroban |
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Potent inhibitor of thrombin mediated fibrinogen cleavage (Ki = 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models.
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| BCC3729 | Axitinib (AG 013736) |
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Potent inhibitor of VEGFR-2, -3, and -1 (IC50 values are 0.2, 0.1-0.3, and 1.2 nM respectively). Exhibits minimal activity against a panel of ~100 protein kinase. Inhibits angiogenesis and vascular permeability. Also a high affinity BCR-ABL1 (T315I) inhibitor (Ki = 149 pM for autophosphorylated ABL1 (T315I)). Blocks proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Orally available.
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| BCC3730 | AZ 628 |
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Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity for Raf kinases over a panel of 150 other kinases; inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Also inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.
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| BCC3731 | AZ3146 |
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Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.
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| BCC3737 | Bexarotene |
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Potent and selective RXR agonist (EC<sub>50</sub> values are 24, 25 and 33 nM for RXR<span class='symbol'>β</span>, RXR<span class='symbol'>γ</span> and RXR<span class='symbol'>α</span>, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration <em>in vitro</em>, and inhibits metastasis and angiogenesis in mouse models.
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| BCC3741 | BMS265246 |
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Potent cdk1/2 inhibitor (IC50 values are 6, 9 and 230 nM for cdk1, cdk2 and cdk4, respectively). Inhibits proliferation of HCT-116 colon cancer cells in vitro.
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