Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 657 - 664 of 9359 hot products
| Catalog No. | Product Name |
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| BCC3781 | Flurbiprofen |
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Potent inhibitor of cyclooxygenase (IC<sub>50</sub> values are 0.1 and 0.4 <span class='symbol'>μ</span>M for inhibition of human COX-1 and COX-2 respectively). Analgesic, anti-inflammatory and antipyretic <em>in vivo</em>. Inhibits tumor cell growth <em>in vitro</em> and <em>in vivo</em>. Regulates prostate stem cell antigen through activation of Akt kinase. Also inhibits fibroblast proliferation <em>in vitro</em>.
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| BCC3782 | Furosemide |
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Loop diuretic that inhibits the Na<sup>+</sup>/2Cl<sup>-</sup>/K<sup>+</sup> (NKCC) symporter. Also acts as a non-competitive antagonist at GABA<sub>A</sub> receptors with ~ 100-fold greater selectivity for <span class='symbol'>α</span>6-containing receptors than <span class='symbol'>α</span>1-containing receptors.
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| BCC3783 | Gabapentin |
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Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca<sup>2+</sup> channels. Prevents neuronal death and is antinociceptive and anxiolytic.
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| BCC3787 | GSK1838705A |
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Potent insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) inhibitor (IC50 values are 1.6 and 2 nM, respectively). Also inhibits anaplastic lymphoma kinase (ALK) (IC50 = 0.5 nM). Displays > 800-fold selectivity for IR, IGFR1 and ALK over a panel of 44 kinases including JNK. Blocks proliferation of cancer cell lines in vitro, and causes complete regression of ALK-dependent tumors in vivo. Orally bioavailable.
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| BCC3790 | GW3965 HCl |
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Selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXR<span class='symbol'>α</span> and hLXR<span class='symbol'>β</span> (EC<sub>50</sub> values are 190 and 30 nM respectively). Reduces angiotensin II-mediated increases in blood pressure; up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.
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| BCC3794 | Indomethacin |
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Cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent.
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| BCC3795 | Ipratropium Bromide |
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Muscarinic antagonist, bronchodilator. N-Isopropyl salt of atropine.
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| BCC3797 | Isradipine (Dynacirc) |
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Potent and selective L-type voltage-gated Ca2+ channel blocker. EC50 and pA2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca2+-induced contractions of rabbit aorta respectively; EC25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo, exerting primary effects on vascular tissue with secondary negative chronotropic action.
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