Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 721 - 728 of 9359 hot products
| Catalog No. | Product Name |
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| BCC3931 | Trovafloxacin mesylate |
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Fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca<sup>2+</sup>. Inhibits Panx-1 (IC<sub>50</sub> ~ 4<span class='symbol'>μ</span>M).
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| BCC3932 | Oxaliplatin |
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Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin and shows antitumor activity in cell lines with acquired cisplatin resistance.
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| BCC3933 | NU 7026 |
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ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC<sub>50</sub> values are 0.23, 13.0, > 100 and > 100 <span class='symbol'>μ</span>M for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.
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| BCC3936 | JK 184 |
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Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC<sub>50</sub> = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI<sub>50</sub> = 3 - 21 nM) and in human xenografts <em>in vivo</em>. Inhibits alcohol dehydrogenase 7 (Adh7) (IC<sub>50</sub> = 210 nM) and acts as a microtubule depolymerizing agent <em>in vitro</em>.
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| BCC3937 | SANT-2 |
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Inhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (K<sub>D</sub> = 12 nM). Displays allosteric binding characteristics similar to SANT-1. Displaces smo-[<sup>3</sup>H]SAG-1.3 and -[<sup>3</sup>H]Cyclopamine binding (K<sub>i</sub> values are 7.8 nM and 8.4 nM respectively).
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| BCC3938 | HPI 1 |
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Hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC<sub>50</sub> values are 1.5, 1.5, 4 and 6 <span class='symbol'>μ</span>M for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC<sub>50</sub> = 2.5 <span class='symbol'>μ</span>M); inhibits the proliferation of cerebellar granule neuron precursors expressing SmoM2. Does not inhibit Wnt signaling.
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| BCC3939 | Ciliobrevin A |
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Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC<sub>50</sub> = 7 <span class='symbol'>μ</span>M) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
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| BCC3940 | AY 9944 dihydrochloride |
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Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits <span class='symbol'>Δ</span><sup>7</sup>-dehydrocholesterol reductase (IC<sub>50</sub> = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic <em>in vivo</em>.
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