Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 777 - 784 of 9359 hot products
| Catalog No. | Product Name |
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| BCC4063 | TCS 1102 |
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Potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). Inhibits ADL-orexin B-mediated locomotion following i.p. administration in vivo and blocks orexin-A (Cat.No.1455) mediated increases in feeding behaviour. Brain penetrant.
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| BCC4069 | Delavirdine mesylate |
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Non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC<sub>50</sub> values are 0.26, 440 and >550 <span class='symbol'>μ</span>M for HIV-1 reverse transcriptase, DNA polymerase <span class='symbol'>α</span> and DNA polymerase <span class='symbol'>δ</span>). Prevents HIV-1 spread <em>in vivo</em> and blocks viral replication in peripheral blood lymphocytes. Orally active.
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| BCC4070 | GSK 650394 |
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Serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC<sub>50</sub> values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC<sub>50</sub> ~ 1 <span class='symbol'>μ</span>M).
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| BCC4073 | Resiquimod (R-848) |
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Toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-<span class='symbol'>γ</span> and iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also promotes the differentiation of MDSCs into macrophages and dendritic cells. Proinflammatory and antiviral.
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| BCC4074 | Icilin |
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Cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC<sub>50</sub> = 0.36 <span class='symbol'>μ</span>M) more potently than menthol or low temperatures. Produces "wet shakes" <em>in vivo</em>.
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| BCC4087 | Angiotensin II human |
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Endogenous potent vasoconstrictor peptide. Stimulates the synthesis and release of aldosterone.
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| BCC4097 | BMS-303141 |
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ATP citrate lyase (ACL) inhibitor (IC<sub>50</sub> = 0.13 <span class='symbol'>μ</span>M for human recombinant ACL); blocks lipid synthesis (IC<sub>50</sub> = 8 <span class='symbol'>μ</span>M in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 <span class='symbol'>μ</span>M. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia. Orally bioavailable.
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| BCC4098 | Marinopyrrole A |
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Mcl-1 inhibitor; disrupts Mcl-1-Bim interaction and induces Mcl-1 proteasomal degradation. Exhibits no effect on Bcl-XL-Bim interaction. Selectively induces apoptosis in Mcl-1-dependent K562 leukemia cells. Sensitizes K562 and Raji cells to ABT-737-induced apoptosis.
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