Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 833 - 840 of 9359 hot products
| Catalog No. | Product Name |
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| BCC4361 | Dorsomorphin 2HCl |
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Potent inhibitor of AMP-activated protein kinase (AMPK) (K<sub>i</sub> = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKC<span class='symbol'>θ</span>, PKA and JAK3. Inhibits AMPK activation induced by ItemId=5334'>AICAR</a> 2840) and ItemId=5367'>metformin</a> 2864). Also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) <em>in vitro</em>. Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
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| BCC4363 | WZ4003 |
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Potent and selective NUAK1/2 inhibitor (IC50 values are 20 and 100 nM respectively). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells.
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| BCC4364 | Flutamide |
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Non-steroidal antiandrogen; competitive antagonist of the androgen receptor. Blocks the biological activity of testosterone <em>in vivo</em>.
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| BCC4365 | Megestrol Acetate |
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Synthetic progesterone analog. Dose-dependently inhibits growth of HepG2 cells (IC50 = 260 μM) in vitro and in vivo and reduces tumor volume. High dosages improve weight gain in tumor-bearing nude mice. Orally bioavailable.
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| BCC4366 | Spironolactone |
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Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity <em>in vivo</em>. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.
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| BCC4370 | Anastrozole |
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Potent and highly selective aromatase (CYP19) inhibitor (IC<sub>50</sub> = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity <em>in vivo</em>. Orally active.
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| BCC4373 | Golgicide A |
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Potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.
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| BCC4374 | Milrinone |
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Potent cAMP phosphodiesterase inhibitor (IC<sub>50</sub> = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration <em>in vivo</em>. Also available as part of the Phosphodiesterase Inhibitor.
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