Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 857 - 864 of 9359 hot products
| Catalog No. | Product Name |
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| BCC4412 | AM251 |
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Potent CB<sub>1</sub> receptor antagonist (IC<sub>50</sub> = 8 nM, K<sub>i</sub> = 7.49 nM) that displays 306-fold selectivity over CB<sub>2</sub> receptors. Also potent GPR55 agonist (EC<sub>50</sub> = 39 nM). Also available in a fluorescent form.
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| BCC4419 | CFTRinh-172 |
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Voltage-independent, selective CFTR chloride channel blocker (K<sub>i</sub> = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and <em>Escherichia coli</em> and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen species (ROS) production independently of CFTR in several cell lines.
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| BCC4428 | Etodolac |
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Non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2) (IC<sub>50</sub> values are 53 and >100 <span class='symbol'>μ</span>M for COX-2 and COX-1 respectively). Displays anti-inflammatory effects in both adjuvant arthritic and normal rats.
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| BCC4435 | Nimesulide |
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Selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo. Reported to produce fewer gastrointestinal side effects than standard NSAIDs. .
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| BCC4439 | Diclofenac Sodium |
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Nonsteroidal, anti-inflammatory drug (NSAID); inhibits COX-1 and COX-2 (IC<sub>50</sub> values are 0.075 <span class='symbol'>μ</span>M for COX-1 and 0.038 <span class='symbol'>μ</span>M for COX-2 in human whole blood assay).
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| BCC4441 | Valdecoxib |
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Selective and potent COX-2 inhibitor (<em>in vitro</em> IC<sub>50</sub> values are 0.005 and 140 <span class='symbol'>μ</span>M for human recombinant COX-2 and COX-1 respectively). Displays potent anti-inflammatory activity <em>in vivo</em>.
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| BCC4447 | Plerixafor 8HCl (AMD3100 8HCl) |
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Highly selective CXCR4 chemokine receptor antagonist (IC<sub>50</sub> values are 0.02 - 0.13 and > 25 <span class='symbol'>μ</span>M for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication <em>in vitro</em> (EC<sub>50</sub> = 4 - 35 nM) and mobilizes hematopoietic stem cells <em>in vivo</em>.
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| BCC4448 | WZ811 |
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Potent chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM).
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