Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 913 - 920 of 9359 hot products
| Catalog No. | Product Name |
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| BCC4596 | VU 0361737 |
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Selective positive allosteric modulator at mGlu4 receptors (EC50 values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. Brain penetrant.
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| BCC4597 | VU 0364770 |
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Positive allosteric modulator at mGlu<sub>4</sub> receptors (EC<sub>50</sub> = 290 nM in mGlu<sub>4</sub>-expressing HEK 293 cells). Reverses haloperidol-induced catalepsy in rats; prevents attentional deficit and forelimb asymmetry in a rodent model of Parkinson's disease. Exhibits affinity for MAO-B and MAO-A (K<sub>i</sub> values are 0.72 <span class='symbol'>μ</span>M and 8.5 <span class='symbol'>μ</span>M respectively). Brain penetrant.
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| BCC4604 | WYE-687 |
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Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC<sub>50</sub> = 7 nM). Displays selectivity for mTOR over PI 3-K<span class='symbol'>α</span> (~100-fold) and PI 3-K<span class='symbol'>γ</span> (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1<span class='symbol'>α</span> expression. Exhibits antiproliferative effects in cancer cell lines through G<sub>1</sub> cell cycle arrest and selective apoptosis.
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| BCC4606 | Torin 2 |
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Potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Activates autophagy. Orally available.
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| BCC4611 | ML130 (Nodinitib-1) |
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Potent and selective inhibitor of NOD1; displays 36-fold selectivity for NOD1 over NOD2 (IC<sub>50</sub> values are 0.56 and >20 <span class='symbol'>μ</span>M for NOD1 and NOD2 respectively). Inhibits NOD1-induced NF-<span class='symbol'>κ</span>B activation in HEK293 cells with no cytotoxicity. Shown to alter subcellular targeting of NOD1; also thought to alter the conformation of NOD1 protein <em>in vitro</em>.
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| BCC4612 | Naloxone HCl |
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Opioid antagonist.
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| BCC4613 | Naltrexone HCl |
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Opioid antagonist.
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| BCC4617 | 7-Aminocephalosporanic acid |
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7-Aminocephalosporanic acid is the core chemical structure for the synthesis of cephalosporin antibiotics, is a potent β-lactamase inhibitor.
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