Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN2673 | (-)-Curine |
| 1. (-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status. | |
| BCN2675 | Daurisoline |
| Daurisoline is a hERG inhibitor and also an autophagy blocker.Daurisoline has antiarrhythmic effects, it( at concentrations below 30 uM) exerts a blocking effect on hERG, but does not affect the expression and function of the hERG channel, it also can inhibit early afterdepolarizations (EADs) which may be associated with its blockade effects on I(Ca-L). Daurisoline and its isomers show cytoprotective effects on ischemic injury in cultured pheochromocytoma (PC12) cells, which are mediated by blocking Ca2+ influx into cells. | |
| BCN2676 | Cucurbitacin S |
| Cucurbitacins from Wilbrandia ebracteata have analgesic effects. Cucurbitacin S has anticancer and antiinflammatory activities. | |
| BCN2677 | Dihydrokavain |
| Dihydrokavain may play an important role in regulation of GABAergic neurotransmission, it non-competitively inhibits the specific binding of [3H]-batrachotoxinin-A 20-alpha-benzoate to receptor site 2 of voltage-gated Na+ channels. Dihydrokavain may treat sleep disturbances, as well as stress and anxiety. | |
| BCN2678 | Embelin |
| Embelin is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay.Embelin has antitumor, antioxidant and anti-inflammatory activities. Embelin can enhance TRAIL-induced cell apoptosis through DR4 and DR5 upregulation and decrease IL-6-induced STAT3 phosphorylation, that combination of low-toxicity Embelin and TRAIL may become as a potential antileukemia strategy. | |
| BCN2679 | Gymnemic acid I |
| 1. Gymnemic acids have been reported to effect a natural treatment for diabetes. 2. Gymnemic acids inhibit rabbit glyceraldehyde-3-phosphate dehydrogenase and induce a smearing of its electrophoretic band and dephosphorylation. | |
| BCN2681 | Homobaldrinal |
| 1. Homobaldrinal has low toxic activity. 2. Homobaldrinal has genotoxic activity in the Salmonella/microsome test and the SOS-chromotest. | |
| BCN2682 | Humulone |
| 1. Humulone has antioxidant activity. 2. Humulone is an antispasmodic agent. 3. Humulone has antiviral and antibacterial activities. 4. Humulone, a bone resorption inhibitor, induces apoptosis may via its antioxidative activity in the premyocytic leukemia cell line HL-60 between 1 and 100 micrograms/ml. 5. Humulone is a potent angiogenic inhibitor, can inhibit cyclooxygenase-2 and may be a novel powerful tool for the therapy of various angiogenic diseases involving solid tumor growth and metastasis. | |
