Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 865 - 872 of 9359 hot products
| Catalog No. | Product Name |
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| BCC4449 | TCID |
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Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC<sub>50</sub> = 0.6 <span class='symbol'>μ</span>M). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.
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| BCC4450 | Adenine |
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Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry. Adenine, an AMP-activated protein kinase (AMPK) activator, can accelerate the diabetic wound healing by PPAR delta and angiogenic regulation; it also can increase the inhibitory activity of human interferon against encephalomyocarditis virus. Adenine can act as an efficient radiation-protecting agent at low concentration (2 micromol) and also inhibit cytostatic properties with regard to cancer cells at higher concentration.
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| BCC4456 | Flupirtine maleate |
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Non-opioid analgesic with muscle relaxant properties. Activates KV7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABAA receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.
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| BCC4459 | Amisulpride |
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Potent, selective dopamine D2 and D3 receptor antagonist. Ki values are 2.8 and 3.2 nM respectively for human D2 and D3 and > 1000 nM for human D1, D4 and D5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2/D3 receptors at higher doses. Preferentially interacts with limbic D2-like receptors in vivo. Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.
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| BCC4460 | Chlorpromazine HCl |
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Dopamine receptor antagonist; reduces neurotransmitter binding. Inhibits nitric oxide synthesis in mouse brain cytosol. Also an antagonist of nAChR, histamine and 5-HT receptors. Displays growth-inhibitory effects on numerous tumor cell lines. Exhibits antipsychotic activity.
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| BCC4461 | Domperidone |
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Peripheral dopamine D2-like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).
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| BCC4463 | Levosulpiride |
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Active enantiomer. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 μM at D2, D3, D4, D1 and D5 receptors respectively).
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| BCC4470 | PYR-41 |
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Cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC<sub>50</sub> < 10 <span class='symbol'>μ</span>M). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-<span class='symbol'>κ</span>B activation, blocks degradation of p53, increases p21 levels and induces apoptosis <em>in vitro</em>. Also causes an increase in sumoylation of proteins.
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