Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 769 - 776 of 9359 hot products
| Catalog No. | Product Name |
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| BCC4029 | ICI 118,551 hydrochloride |
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Very selective <span class='symbol'>β</span><sub>2</sub> adrenergic antagonist (K<sub>i</sub> values are 1.2, 120 and 257 nM for <span class='symbol'>β</span><sub>2</sub>, <span class='symbol'>β</span><sub>1</sub> and <span class='symbol'>β</span><sub>3</sub> receptors respectively). Active <em>in vivo</em>. Also available as part of the<span class='symbol'>β</span>-Adrenoceptor Antagonist.
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| BCC4037 | MS436 |
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Potent and selective BRD4 bromodomain inhibitor (K<sub>i</sub> = 30 - 50 nM for the first bromodomain (BRD4(1)). Exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC<sub>50</sub> values are 3.8 and 4.9 <span class='symbol'>μ</span>M, respectively). Attenuates melanoma cell proliferation <em>in vitro</em>.
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| BCC4039 | XL413 hydrochloride |
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Potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice.
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| BCC4042 | (S)-(+)-Ibuprofen |
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Non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase 1 and cyclooxygenase 2 (IC<sub>50</sub> values are 12 and 80 <span class='symbol'>μ</span>M respectively). Active isomer of ibuprofen.
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| BCC4048 | 2-Deoxy-D-glucose |
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Non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR).
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| BCC4052 | (3S,4S)-Tofacitinib |
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(3S,4S)-Tofacitinib is the S-enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC50 of 1 nM.
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| BCC4053 | VU0152100 |
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Selective positive allosteric modulator of M<sub>4</sub> muscarinic acetylcholine receptors (mAChRs) (EC<sub>50</sub> = 380 nM). Induces 21-fold shift in ACh potency at M<sub>4</sub> receptor. Displays no activity at other mAChR subtypes.
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| BCC4059 | MDL-29951 |
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Potent, selective antagonist at the glycine-NMDA site (IC50 = 140 nM against glycine binding). Displays 2500-fold selectivity for the glycine vs. glutamate binding site.
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