Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN2505 | Lappaconitine Hydrobromide |
| Lappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias, it is a selective blocker of the TTX-sensitive Na+ channels, and does not influence on the activation threshold of Na+ channels. Lappaconitine hydrobromide can be used for local anesthesia, and analgesic treatment. Lappaconitine hydrobromide has anti-inflammatory effects, it can remove inflammation and swelling, lower temperature and relieve heat. | |
| BCN2507 | Lycorenine |
| 1. The development of tachyphylaxis to the vasodepressor action of lycorenine is ascribed to maintenance of its alpha-adrenergic blocking action. 2. Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. | |
| BCN2508 | Schisanhenol |
| Schisanhenol has antioxidative effect on human LDL oxidation, may be through scavenging free radicals; it also has anti-apoptosis effect on BACSs, may be related to its inhibition of ROS generation. Schisanhenol can protect against adriamycin induced heart mitochondrial toxicity. | |
| BCN2509 | 11-Oxo-mogroside V |
| 11-Oxo-mogroside V is a natural sweetener, exhibits strong antioxidant activity. It exhibits significant inhibitory effects on reactive oxygen species (O2-, H2O2 and *OH) with EC50 of 4.79, 16.52, and 146.17 μg/mL, respectively. 11-Oxo-mogroside V exhibits the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumor induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. | |
| BCN2511 | 12-O-tetradecanoylphorbol-13-acetate |
| 1. 12-O-tetradecanoylphorbol-13-acetate has skin tumor-promoting potential. 2. 12-O-tetradecanoylphorbol-13-acetate induces endogenous FBXO10 mRNA and FBXO10 protein in Jurkat cells, a human T cell line. 3. 12-O-tetradecanoylphorbol-13-acetate provokes cell motility through regulating the expression and function of S100A14 in a KLF4-dependent manner. | |
| BCN2512 | 12-O-Tiglylphorbol-13-isobutyrate |
| 1. 12-O-Tetradecanoylphorbol-13-acetate has cytotoxic against in vitro P-388 lymphocytic leukemia and KB nasopharyngeal carcinoma cell. | |
| BCN2513 | Isotanshinone IIB |
| 1. Tanshinol protects against hydrogen peroxide-induced oxidative stress via regulating Wnt/FoxO pathway in osteoblastic differentiation of C2C12 cells. 2. Tanshinol protects hippocampus and attenuates vascular dementia development, it may be a potential compound in vascular dementia (VD) model. 3. Tanshinol protects against atherosclerosis by preventing H2O2-induced apoptosis of human umbilical vein endothelial cells (HUVECs), these effects appear to be mediated by enhancing the antioxidant defenses and preserving the mitochondrial function of the cells. 4. Tanshinol can stimulate bone formation and attenuate dexamethasone-induced inhibition of osteogenesis in larval zebrafish. 5. Tanshinol attenuates oxidative stress via down-regulation of FoxO3a signaling, and rescues the decrease of osteoblastic differentiation through upregulation of Wnt signal under oxidative stress. | |
| BCN2514 | 7-Epitaxol |
| 7-Epitaxol is the major derivative of taxol found in cells and taxol (paclitaxel) is a well-known natural-source cancer drug. | |
