Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN2497 | Hydroxytanshinone IIA |
| 1. Hydroxytanshinone ⅡA has good antiproliferative effect on SGC-7901,HeLa, and HepG 2 cell, the values of IC50 are 4.18, 6.08 and10.20 uM, respectively; it has tumor cell proliferation inhibition significantly stronger than the tanshinoneⅡA . | |
| BCN2498 | Isochlorogenic acid C |
| 1. Isochlorogenic acid C(4,5) has antiviral activity, including anti-HIV-1 integrase activity. 2. Isochlorogenic acid C(4,5) shows anti-hepatotoxic activity. | |
| BCN2499 | Isocryptotanshinone |
| 1. Isocryptotanshinone inhibits MCF-7 cell proliferation by inducing apoptosis and activating MAPK signaling pathways. 2. Isocryptotanshinone is a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. 3. Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM. (1) PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. | |
| BCN2500 | Isotanshinone I |
| 1. Isotanshinone I ,neotanshinone A and cryptotanshinone have different effects on inhibiting proteic activity of P38 and NF-κB signaling pathway,and this effect may be one of main mechanisms of inhibitive inflammation reaction by salvia miltiorrhiza bunge in liver. | |
| BCN2501 | Isotanshinone IIA |
| 1. Isotanshinone IIA non-competitively inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 11.4±0.6 μM. (1) PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. | |
| BCN2502 | Isovanillin |
| Isovanillin is a reversible inhibitor of aldehyde oxidase. It is largely used as pharmaceutical intermediates and also applied in food and beverage industry, synthetic fragrances, chemical. Isovanillin is a selective inhibitor of aldehyde oxidase, is metabolized by aldehyde dehydrogenase into isovanillic acid ,and the LD50 (rat, ipr) is 1276 mg/kg. | |
| BCN2503 | Kaempferol-3-beta-O-glucuronide |
| 1. Kaempferol-3-beta-O-glucuronide has antioxidant activity. 2. Flavonoid glucuronides can be deconjugated by microsomal β-glucuronidase from various human cells. | |
| BCN2504 | Lannaconitine |
| 1. Lappaconitine has neurotoxic and cardiotoxic. 2. Lappaconitine has a strong analgesic activity that does not involve the opioid receptor, has class-I antiarrhythmic action and irreversibly blocks cloned human heart (hH1) channels by binding to the site 2 receptor. | |
