Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 761 - 768 of 9359 hot products
| Catalog No. | Product Name |
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| BCC4001 | NH125 |
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Eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC<sub>50</sub> = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Decreases the viability of a variety of cancer cell lines (IC<sub>50</sub> values are 0.7 - 4.8 <span class='symbol'>μ</span>M) and blocks G<sub>1</sub>/S cell cycle progression. Shown to induce eEF-2 phosphorylation in cancer cells. Also an effective antibacterial agent; inhibits histidine protein kinase <em>in vitro</em> (IC<sub>50</sub> = 6.6 <span class='symbol'>μ</span>M) and <em>in vivo</em>.
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| BCC4003 | ZIP |
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Novel, cell-permeable inhibitor of protein kinase M<span class='symbol'>ζ</span> (PKM<span class='symbol'>ζ</span>), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKM<span class='symbol'>ζ</span>-induced synaptic potentiation in hippocampal slices <em>in vitro</em>. Reverses late-phase LTP (IC<sub>50</sub> = 1 - 2.5 <span class='symbol'>μ</span>M) and produces persistent loss of 1-day-old spatial memory following central administration <em>in vivo</em>. Control and biotinylated peptides also available.
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| BCC4007 | Ro 3306 |
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ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively). Induces G2/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML).
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| BCC4010 | HTH-01-015 |
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Potent and selective NUAK1 inhibitor (IC50 = 100 nM). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells in vitro, to a similar extent as NUAK1 knockdown models.
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| BCC4011 | WWL 70 |
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Potent inhibitor of <span class='symbol'>α</span>/<span class='symbol'>β</span>-hydrolase domain 6 (ABHD6) (IC<sub>50</sub> = 70 nM), an enzyme which catalyzes the hydrolysis of 2-arachidonylglycerol.
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| BCC4014 | (+)-MK 801 Maleate |
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A potent, selective and non-competitive NMDA receptor antagonist. Acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca<sup>2+</sup> flux. An effective anti-ischemic agent in several animal models. Part of the Mixed NMDA Receptor. (-)-MK 801 maleate also available.
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| BCC4022 | Ac-YVAD-AFC |
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Fluorogenic peptide substrate for caspase-1 (ICE).
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| BCC4027 | Tropisetron Hydrochloride |
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Potent, orally active 5-HT<sub>3</sub> receptor antagonist. Antiemetic. Also partial agonist of <span class='symbol'>α</span>7 nAChR.
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