Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN2763 | Valechlorine |
| 1. Valeranone shows antileishmanial and cytotoxic activity. | |
| BCN2764 | Goitrin |
| 1. Goitrin is a potent antithyroid compound found naturally in crucifers. 2. Goitrin is responsible for the induction of glutathione S-transferases. 3. Goitrin is a moderate inhibitor of purified bovine adrenal dopamine beta-hydroxylase, leads to a depression of brain norepinephrine and to an elevation of heart and adrenal dopamine. | |
| BCN2765 | Sinapine thiocyanate |
| Sinapine thiocyanate has antioxidant activities and is hepatoprotective in a dose-dependent manner, implies that Brassica rapa seeds could be developed as a functional food for hepatoprotection. | |
| BCN2766 | Isodemethylwedelolacton |
| Isodemethylwedelolactone is a natural product from the Eclipta prostrata. | |
| BCN2767 | Beta,beta-Dimethylacrylalkannin |
| Beta,beta-Dimethylacrylalkannin has radical scavenging activity, it exhibits inhibitory activities on PTP1B with IC50 values of 0.36±0.08 umol·L-1, it may be a new type of leading compounds for the treatment of diabetes. Beta,beta-Dimethylacrylalkannin has great potential as topo I inhibitors compared to other compounds and CPT-11, with 2-3uM inhibition value. Beta,beta-Dimethylacrylalkannin can be potential therapeutics against tumor cell growth because of its unique DNA damaging abilities additional to enzyme inhibition similar to those of doxorubicin. | |
| BCN2768 | Heterophyllin B |
| Heterophyllin B is used as the quality control index for evaluating P. heterophylla in the Chinese Pharmacopoeia.Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associated genes. | |
| BCN2769 | Asarinin |
| Asarinin, a mammalian lignan precursor, has immunosuppression activity and can inhibit acute rejection in vitro. Asarinin may have a role on TLR4 pathway and produce prolongation of allograft heart survival. Asarinin induces dopamine biosynthesis via activation of the PKA-CREB-TH system and protects against 6-OHDA-induced cytotoxicity by inhibiting the sustained activation of the ERK-p38MAPK-JNK1/2-caspase-3 system in PC12 cells. | |
| BCN2770 | Tussilagone |
| Tussilagone has anti-cancer, anti-oxidant and anti-inflammatory activities. Tussilagone inhibits dendritic cell function through the induction of heme oxygenase-1; it has potential treatment of neuro-inflammatory diseases through the inhibition of overproduction of nitric oxide and prostaglandin E(2). | |
