Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1041 - 1048 of 9359 hot products
| Catalog No. | Product Name |
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| BCC4976 | MRS 2578 |
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Selective antagonist of P2Y<sub>6</sub> nucleotide receptors; IC<sub>50</sub> values are 37 and 98 nM at human and rat P2Y<sub>6</sub> receptors respectively. Displays no activity at P2Y<sub>1</sub>, P2Y<sub>2</sub>, P2Y<sub>4</sub> and P2Y<sub>11</sub> receptors (IC<sub>50</sub> > 10 <span class='symbol'>μ</span>M). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.
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| BCC4978 | IPA-3 |
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Group I p21-activated kinase (PAK) inhibitor (IC<sub>50</sub> = 2.5 <span class='symbol'>μ</span>M at PAK1). Targets the autoregulatory mechanism and promotes the inactive conformation of PAKs. Inhibits PAK1-mediated signaling <em>in vivo</em>; potential anti-tumor agent. Negative control PIR 3.5 available.
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| BCC4980 | PP121 |
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Dual inhibitor of receptor tyrosine kinases (RTKs) (IC<sub>50</sub> < 0.02 <span class='symbol'>μ</span>M for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC<sub>50</sub> < 0.06 <span class='symbol'>μ</span>M for p110<span class='symbol'>α</span>, DNA-PK and mTOR). Exhibits no significant effect on receptor serine/threonine kinases (RSTKs). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor.
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| BCC4982 | GSK2334470 |
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Potent 3-phosphoinositide-dependent protein kinase (PDPK1) inhibitor (IC50 ~ 10 nM). Exhibits no effect on other kinases including Aurora, ROCK, p38 MAPK and PI 3-K. Suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK and RSK in vitro; exhibits limited inhibitory effect on Akt activation. Delays melanomagenesis and metastasis in BrafV600E::Pten(-/-) mice.
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| BCC4984 | GSK1059615 |
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Potent inhibitor of PI 3-kinase <span class='symbol'>α</span> (PI3K<span class='symbol'>α</span>) (IC<sub>50</sub> = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.
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| BCC4985 | TG100713 |
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Inhibitor of PI3-kinase (IC<sub>50</sub> values are 24, 50, 165 and 215 nM for PI3K<span class='symbol'>δ</span>, <span class='symbol'>γ</span>, <span class='symbol'>α</span> and <span class='symbol'>β</span> isoforms respectively). Inhibits endothelial cell proliferation.
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| BCC4987 | PF-05212384 (PKI-587) |
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Potent and selective dual inhibitor of PI 3-kinase/mTOR (IC<sub>50</sub> values are 0.4, 1.6 and 5.4 nM for PI 3-K<span class='symbol'>α</span>, mTOR and PI 3-K<span class='symbol'>γ</span> respectively). Exhibits selectivity over 234 other protein kinases (IC<sub>50</sub> >10 <span class='symbol'>μ</span>M). Potently inhibits tumor cell growth in 37 different tumor cell lines (IC<sub>50</sub> < 100 nM). Also exhibits antitumor activity in MDA-361, HCT-116, H1975 and U87MG xenograft models.
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| BCC4988 | AS-252424 |
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Potent and selective inhibitor of PI 3-kinase <span class='symbol'>γ</span> (IC<sub>50</sub> values are 33 and 935 nM for PI 3-K<span class='symbol'>γ</span> and PI 3-K<span class='symbol'>α</span> respectively).
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