Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1065 - 1072 of 9359 hot products
| Catalog No. | Product Name |
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| BCC5028 | Stavudine (d4T) |
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Nucleoside analog; antiviral that inhibits HIV replication in vitro. Orally bioavailable.
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| BCC5029 | SKI II |
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Selective non-lipid inhibitor of sphingosine kinase (IC<sub>50</sub> = 0.5 <span class='symbol'>μ</span>M); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKC<span class='symbol'>α</span> at concentrations up to 60 <span class='symbol'>μ</span>M. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines <em>in vitro</em> (IC<sub>50</sub> = 0.9 - 4.6 <span class='symbol'>μ</span>M).
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| BCC5031 | PF-4708671 |
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Cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (Ki = 20 nM; IC50 = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK in vivo. Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro.
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| BCC5032 | Trazodone HCl |
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5-HT2A and α1 adrenoceptor antagonist. Enhances neuronal differentiation of mouse and human neural progenitor cells. Also inhibits PERK/eIF2α-P-mediated reduction in protein synthesis and restores memory deficits in a mouse dementia model. Antidepressant and neuroprotectant.
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| BCC5033 | Amitriptyline HCl |
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Inhibitor of serotonin and noradrenaline uptake; also activates <span class='symbol'>α</span><sub>2A</sub>-adrenoceptors and antagonizes 5-HT<sub>2</sub> receptors. Displays antinociceptive activity. Tricyclic antidepressant (TCA). Also a TrkA/B agonist. Induces neurite outgrowth in PC12 cells.
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| BCC5034 | Aripiprazole |
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High affinity dopamine D2 and 5-HT1A receptor partial agonist (Ki values are ~1.64 and 5.59 nM respectively). Also 5-HT2A antagonist (Ki = 8.7 nM). Suppresses morphine-induced emesis in vivo. Atypical antipsychotic.
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| BCC5035 | Azasetron HCl |
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A selective and potent 5-HT<sub>3</sub> antagonist (K<sub>i</sub> = 2.9 nM).
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| BCC5036 | Clomipramine HCl |
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Potent, selective 5-HT uptake blocker. Antidepressant. Binds to the human 5-HT transporter with a K<sub>i</sub> of 0.05 nmol/l.
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