Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN2934 | Terrestrosin D |
| 1. Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of actions for the observed antitumor and antiangiogenic activities of terrestrosin D. | |
| BCN2939 | Cassiaside |
| 1. Cassiaside and emodi show mixed-type inhibition against β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1). 2. Cassiaside demonstrates significant antimutagenic activity. 3. Cassiaside shows 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical scavenging effect. 4. Cassiaside has significant hepato-protective effects against galactosamine damage, which is higher than that of silybin from Silybum marianum. | |
| BCN1476 | Rubrofusarin-6-O-beta-D-gentiobioside |
| 1. Rubrofusarin-6-O-beta-D-gentiobioside can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it has potential as a preventive agent for advanced glycation end products-related diabetic complications. | |
| BCN2941 | 6'-O-Galloyl paeoniflorin |
| 1. Galloylpaeoniflorin, gallic acid, paeoniflorin, and paeonol are the main effective components of Moutan Cortex, Moutan Cortex exhibits good activity on acute lung injury. 2. Galloylpaeoniflorin exhibits anticomplement effects. 3. Galloylpaeoniflorin reveals a more pronounced radical scavenging effect than a-tocopherol. 4. Galloylpaeoniflorin can take part in improving blood circulation by inhibiting ether platelet aggregation and/or blood coagulation. | |
| BCN2942 | Zingiberen newsaponin |
| 1. Zingiberensis newsaponin I exhibits induction effect on platelet aggregation. 2. Zingiberensis saponin can inhibit the proliferation of a panel of established human and murine cancer cell lines in vitro, its proliferation inhibitory effect is associated with its apoptosis-inducing effect by activation of caspase-3 and caspase-9 and specific proteolytic cleavage of poly (ADP-ribose) polymerase, thus, zingiberensis saponin is an effective natural agent for cancer therapy. | |
| BCN2945 | Kuwanon H |
| 1. Kuwanon H, and possibly kuwanon G also, are specific antagonists for the gastrin-releasing peptide (GRP) -preferring receptor and can be useful for studying the physiological and pathological role of GRP. | |
| BCN2946 | Sanggenone H |
| Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α and IL-1β and inhibited the NF-κB nuclear translocation in LPS-stimulated macrophages. | |
| BCN2947 | 10-Deacetyl-7-xylosyl paclitaxel |
| 1. 10-Deacetyl-7-xylosyl paclitaxel has long been used in Chinese clinics to treat cancer, it may target mitochondrial permeability transition pore (mPTP). | |
