Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1113 - 1120 of 9359 hot products
| Catalog No. | Product Name |
|---|---|
| BCC5129 | Vanoxerine dihydrochloride |
|
Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
|
|
| BCC5139 | Balicatib |
|
Potent and selective cathepsin K inhibitor (IC50 values are 1.4, 56 and 480 nM for human, rat and mouse cathepsin K, respectively). Exhibits >300-fold selectivity for cathepsin K over cathepsins L, B and S. Long term supratherapeutic dosing increases tissue levels of cathepsins L and B in rats.
|
|
| BCC5141 | AHU-377 hemicalcium salt |
|
Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug. Increases ANF-induced natriuresis without affecting diuresis in rats. Orally bioavailable.
|
|
| BCC5148 | TCS JNK 5a |
|
Selective inhibitor of JNK2 and JNK3 (pIC<sub>50</sub> values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38<span class='symbol'>α</span> respectively). Displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC<sub>50</sub> < 5.0).
|
|
| BCC5151 | BQ-788 sodium salt |
|
Potent, selective ET<sub>B</sub> receptor antagonist (IC<sub>50</sub> = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).
|
|
| BCC5160 | ATP disodium salt |
|
P2 purinoceptor agonist.
|
|
| BCC5161 | Cyproheptadine hydrochloride |
|
Non-selective 5HT<sub>2</sub> antagonist, migraine prophylactic. Also SETD7/9 inhibitor (IC<sub>50</sub> = 1<span class='symbol'>μ</span>M). Decreases expression and increases degradation of estrogen receptor (ER) <span class='symbol'>α</span> in breast tumor MCF7 cells. Inhibits growth of MCF7 xenografts in mice.
|
|
| BCC5163 | Moxonidine hydrochloride |
|
Mixed I<sub>1</sub> imidazoline receptor and <span class='symbol'>α</span><sub>2</sub>-adrenergic agonist; displays 40-fold higher affinity for I<sub>1</sub> receptors versus <span class='symbol'>α</span><sub>2</sub>-adrenoceptors. Centrally acting antihypertensive agent.
|
|