Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN6526 | Continentalic acid |
| 1. Continentalic acid and kaurenoic acid are quality control markers in Aralia continentalis. 2. Continentalic acid shows moderate cytotoxicity against A-549 (lung), THP-1 (leukemia) and MCF-7 (breast) cell lines. 3. Continentalic acid exerts significant anti-inflammatory activity. 4. Continentalic acid can efficiently induces apoptosis and is a good candidate for further evaluation as an effective chemotherapeutic agent. 5. Continentalic acid has minimum inhibitory concentrations (MICs) of approximately 8-16 microg/mL against S. aureus, including the MSSA and MRSA standard strains. | |
| BCN6527 | Perillen |
| Perillen is a nartural product from Perilla frutescens. | |
| BCN6529 | Guvacine |
| meso-Hannokinol and (+)-hannokinol can significantly inhibit lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 1 uM to 100 uM. | |
| BCN6709 | Maltotetraose |
| 1. Maltotetraose and stachyose are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in the suppression of early atherosclerosis development and could be developed as a dietary supplement for cardiovascular health. | |
| BCN6762 | Trimethoxystilbene |
| 3,4',5-Trimethoxystilbene, an inhibitor of tubulin polymerization, which exerts antitumor, anti-HCV, antiallergic, anti-mitotic properties, it also exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation. 3,4',5-Trimethoxystilbene has anti-inflammatory activity, the ability of it to induce HO-1 expression may provide one of possible mechanisms of its anti-inflammatory action. | |
| BCN6769 | Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose |
| 1. Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose can moderately inhibit α-amylase activity, with the IC50 value of 0.03 umol/ml. | |
| BCN6770 | Brandioside |
| 1. Brandioside exhibits significant inhibition of advanced glycation end product formation with the IC50 value of 4.6-25.7 uM. 2. Brandioside significantly attenuates glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 microM. 3. Brandioside shows inhibition of smooth muscle cell proliferation, indicates that it may have preventative effects on arteriosclerosis. 4. Brandioside shows strong antioxidant effect. | |
| BCN6791 | Cytosporone B |
| Cytosporone B is a naturally occurring agonist for Nur77, it also is a Salmonella pathogenicity island 1 (SPI-1)-inhibitor, it may have potential in drug development against antibiotic-resistant Salmonella. Cytosporone B can elevate blood glucose levels in fasting C57 mice, an effect that is accompanied by induction of multiple genes involved in gluconeogenesis. Cytosporone B can inhibit transforming growth factor-b (TGF-β)-induced contraction of human corneal fibroblasts (HCFs), likely as a result of its attenuation of the up-regulation of α-SMA expression. | |
