Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1105 - 1112 of 9359 hot products
| Catalog No. | Product Name |
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| BCC5101 | IWP-L6 |
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Potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM). Shown to inhibit Wnt-dependent processes such as tailfin regeneration and posterior axis formation in zebrafish; also reduces branching morphogenesis in cultured mouse embryonic kidneys.
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| BCC5102 | IWR-1-endo |
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Inhibitor of Wnt signaling. Induces an increase in Axin2 protein levels; promotes <span class='symbol'>β</span>-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Negative control <em>exo</em>-IWR available.
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| BCC5105 | Bay 11-7085 |
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Irreversible inhibitor of TNF-<span class='symbol'>α</span>-stimulated I<span class='symbol'>κ</span>B<span class='symbol'>α</span> phosphorylation (IC<sub>50</sub> ~ 10 <span class='symbol'>μ</span>M); leads to decreased NF-<span class='symbol'>κ</span>B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory <em>in vivo</em>.
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| BCC5108 | CORM-3 |
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Water-soluble carbon monoxide-releasing molecule. Suppresses thrombin-induced nitrite release in BV-2 microglia. Protects isolated rats hearts from reperfusion damage in vitro and is cardioprotective in a rat myocardial infarction model in vivo. Also prolongs survival of transplanted hearts in mice. Exhibits anti-inflammatory and vasorelaxant effects.
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| BCC5110 | FLI-06 |
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Inhibitor of Notch signaling (EC<sub>50</sub> = 2.3 <span class='symbol'>μ</span>M). Disrupts Notch trafficking and processing. Reduces amyloid <span class='symbol'>β</span> secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets.
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| BCC5111 | PTC-209 |
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Bmi-1 inhibitor (IC<sub>50</sub> ~ 0.5 <span class='symbol'>μ</span>M); irreversibly impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors<em> in vivo</em>.
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| BCC5120 | AV-412 free base |
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Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases (IC50 values are 0.5-2, 19 and 41 nM, respectively). Also weak inhibitor of FLT1 and Src. Inhibits EGFR and ErbB2 autophosphorylation in vitro in NSCLC and T-47D breast cancer cell lines, respectively. Inhibits tumor growth of EGFR-overexpressing A431 and ErbB2 overexpressing BT-474 tumor xenografts in mice.
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| BCC5121 | XCT790 |
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Selective ERR<span class='symbol'>α</span> antagonist/inverse agonist (IC<sub>50</sub> = ~400 nM). Displays no antagonist activity at ERR<span class='symbol'>γ</span> or ER<span class='symbol'>α</span> at concentrations below 10 <span class='symbol'>μ</span>M. Interferes with PPAR<span class='symbol'>γ</span> coactivator-1<span class='symbol'>α</span> (PGC-1<span class='symbol'>α</span>)/ERR<span class='symbol'>α</span>-dependent signaling: inhibits PGC-1<span class='symbol'>α</span> induction of ERR<span class='symbol'>α</span> and MAO-B gene expression and downregulates the constitutive transcriptional activity of ERR<span class='symbol'>α</span> in numerous cell lines.
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