Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1049 - 1056 of 9359 hot products
| Catalog No. | Product Name |
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| BCC4997 | H 89 2HCl |
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Protein kinase A inhibitor that also inhibits several other kinases (IC<sub>50</sub> values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKB<span class='symbol'>α</span> and MAPKAP-K1b). Exhibits antinociceptive activity. Also available as part of the PKA<sup>TM</sup>.
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| BCC4998 | Dequalinium Chloride |
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A potent and selective non-peptide blocker of the apamin-sensitive small conductance Ca2+-activated K+ channel (IC50 = 1.1 mM).
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| BCC4999 | Ro 31-8220 Mesylate |
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Protein kinase C inhibitor, with activity at other protein kinases (IC<sub>50</sub> values are 33, 3, 8, 15 and 38 nM for PKC<span class='symbol'>α</span>, MAPKAP-K1b, MSK1, GSK3<span class='symbol'>β</span> and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na<sup>+</sup> channels in the micromolar range.
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| BCC5003 | Gliquidone |
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Gliquidone is an anti-diabetic drug in the sulfonylurea class, used in the treatment of diabetes mellitus type 2.
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| BCC5004 | Nicorandil |
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K<sub>ir</sub>6 (K<sub>ATP</sub>) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing K<sub>ir</sub>6 channels (EC<sub>50</sub> values are 10 and > 500 <span class='symbol'>μ</span>M respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.
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| BCC5005 | Nateglinide |
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K<sub>ir</sub>6 (K<sub>ATP</sub>) blocker. Exhibits <em>in vitro</em> tissue selectivity for pancreatic <span class='symbol'>β</span>-cell-type K<sub>ir</sub>6 channels over cardiovascular K<sub>ir</sub>6 channels; displays high affinity for SUR1/K<sub>ir</sub>6.2 channels. Hypoglycemic agent; stimulates insulin secretion from pancreatic <span class='symbol'>β</span>-cells by increasing cytosolic Ca<sup>2+</sup> concentration.
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| BCC5006 | ML133 HCl |
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Selective blocker of inwardly rectifying K<sub>ir</sub>2 potassium channels (IC<sub>50</sub> values are 1.8, 2.8, 2.9 and 4.0 <span class='symbol'>μ</span>M at pH 7.4 for mK<sub>ir</sub>2.1, hK<sub>ir</sub>2.6, hK<sub>ir</sub>2.2 and hK<sub>ir</sub>2.3 respectively). Exhibits no effect on rK<sub>ir</sub>1.1 (IC<sub>50</sub> > 300 <span class='symbol'>μ</span>M); displays weak activity at hK<sub>ir</sub>7.1 and rK<sub>ir</sub>4.1 (IC<sub>50</sub> values are 33 and 76 <span class='symbol'>μ</span>M).
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| BCC5010 | PD123319 |
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Potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
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