Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1337 - 1344 of 9359 hot products
| Catalog No. | Product Name |
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| BCC5734 | ZD 7155 hydrochloride |
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A potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. Displaces [125I]-angiotensin II binding with an IC50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT1 antagonist, losartan.
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| BCC5735 | DL-TBOA |
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A competitive, non-transportable blocker of excitatory amino acid transporters (IC<sub>50</sub> values are 70, 6, and 6 <span class='symbol'>μ</span>M for EAAT1, EAAT2 and EAAT3 respectively). Also inhibits EAAT4 and EAAT5 (K<sub>i</sub> values are 4.4 and 3.2 <span class='symbol'>μ</span>M respectively). Displays high selectivity for EAATs over ionotropic and metabotropic glutamate receptors. Also available as part of the Excitatory Amino Acid Transporter Inhibitor.
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| BCC5736 | Ac-RYYRIK-NH2 |
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High affinity ligand for the NOP site (K<sub>i</sub> = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties <em>in vivo</em>, inhibiting locomotor activity in mice.
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| BCC5737 | CGP 55845 hydrochloride |
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Potent, selective GABAB receptor antagonist (IC50 = 5 nM) that prevents agonist binding (pKi = 8.35) and inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85 respectively). Inhibits GABAB responses to baclofen (IC50 = 130 nM in an isoproterenol assay) and potentiates the hypoglycemic response to glucose in vitro.
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| BCC5738 | Nociceptin (1-7) |
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Bioactive metabolite of nociceptin. Antagonizes nociceptin-induced hyperalgesia, with no effect on nociceptin-induced analgesia.
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| BCC5739 | [Nphe1]Nociceptin(1-13)NH2 |
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Selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pK<sub>i</sub> = 8.4), and competitively antagonizes the actions of nociceptin <em>in vitro</em> and <em>in vivo</em>.
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| BCC5740 | Tertiapin-Q |
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A high affinity blocker for inward-rectifier K<sup>+</sup> channels, this compound is a stable derivative of the bee venom toxin tertiapin. Binds to ROMK1 (K<sub>ir</sub>1.1) and GIRK1/4 (K<sub>ir</sub>3.1/3.4) channels with high affinity (K<sub>i</sub> values are 1.3 and 13.3 nM respectively) and is selective over K<sub>ir</sub>2.1 channels. Derivative tertiapin LQ also available.
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| BCC5741 | RS 100329 hydrochloride |
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Subtype-selective <span class='symbol'>α</span><sub>1A</sub>-adrenoceptor antagonist (pK<sub>i</sub> = 9.6 for human cloned <span class='symbol'>α</span><sub>1A</sub> receptors). Displays 126- and 50-fold selectivity over human <span class='symbol'>α</span><sub>1B</sub> and <span class='symbol'>α</span><sub>1D</sub> receptors respectively. Active <em>in vivo</em>.
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