Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1377 - 1384 of 9359 hot products
| Catalog No. | Product Name |
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| BCC5775 | UFP-101 |
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Potent, selective and competitive silent antagonist for the NOP opioid receptor. Binds to NOP with high affinity (pK<sub>i</sub> = 10.24) and displays > 3000-fold selectivity over <span class='symbol'>δ</span>, <span class='symbol'>μ</span> and <span class='symbol'>κ</span> opioid receptors. Antinociceptive and opposes the action of nociceptin <em>in vivo</em>.
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| BCC5776 | CTAP |
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Potent and selective <span class='symbol'>μ</span> opioid receptor antagonist (IC<sub>50</sub> = 3.5 nM). Displays > 1200-fold selectivity over <span class='symbol'>δ</span> opioid and somatostatin receptors. Brain penetrant and active <em>in vivo</em>.
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| BCC5777 | JIP-1 (153-163) |
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Peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK.
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| BCC5778 | [(pF)Phe4]Nociceptin(1-13)NH2 |
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Highly potent and selective nociceptin/orphanin FQ receptor (OP<sub>4</sub>) agonist peptide (pK<sub>i</sub> = 10.68; pEC<sub>50</sub> = 9.80). Displays > 8000-fold selectivity over <span class='symbol'>δ</span>, <span class='symbol'>κ</span>, and <span class='symbol'>μ</span> opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects <em>in vivo</em>.
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| BCC5779 | L-R4W2 |
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Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC<sub>50</sub> ~ 0.1 <span class='symbol'>μ</span>M); blocks Ca<sup>2+</sup> currents in dorsal root ganglion neurons. Analgesic <em>in vivo</em>.
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| BCC5780 | CTOP |
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Potent and selective <span class='symbol'>μ</span> opioid receptor antagonist (K<sub>i</sub> values are 0.96 and >10,000 nM for <span class='symbol'>μ</span> and <span class='symbol'>δ</span> receptors respectively). Causes behavioral effects on central administration <em>in vivo</em>. Also increases K<sup>+</sup> currents in rat locus ceruleus neurons <em>in vitro</em> via a <span class='symbol'>μ</span> receptor independent mechanism.
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| BCC5781 | [Arg14,Lys15]Nociceptin |
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Highly potent and selective NOP receptor agonist (EC<sub>50</sub> = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC<sub>50</sub> values are 0.32, 280, > 10000 and 1500 for NOP, <span class='symbol'>μ</span>, <span class='symbol'>δ</span> and <span class='symbol'>κ</span> receptors respectively). Longer lasting and 30-fold more potent than nociceptin <em>in vivo</em>; pronociceptive and inhibits locomotor activity.
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| BCC5782 | pep2m |
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Peptide inhibitor of the interaction between the C-terminus of the GluR2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces postsynaptic currents in CA1 neurons, AMPA-mediated currents in cultured hippocampal neurons and AMPA receptor surface expression. Control peptide pep4c also available.
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