Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN3157 | Microstegiol |
| 1. Migrostegiol has a little activity against B. subtilis. | |
| BCN3158 | Neocryptotanshinone |
| 1. Neocryptotanshinone inhibits rabbit platelet aggregation induced by arachidonic acid. | |
| BCN3160 | Prionoid D |
| 1. Prionoid D (IC50 = 0.41 microM) shows significant cytotoxic activity against P-388 cell lines. | |
| BCN3161 | Prionoid E |
| 1. Prionoid E (IC50 = 0.72 microM) shows significant cytotoxic activity against A-549 cell lines. | |
| BCN3163 | Salvicine |
| 1. Salvicine inactivates β1 integrin and inhibits integrin-mediated cell adhesion to fibronectin. 2. Specificity of Salvicine and diversity of anticancer agents in the mechanism of interference with telomerase and the telomere system. 3. Salvicine has potent anti-angiogenic activity through the inhibition on the sequential angiogenic cascades: proliferation, migration and tube formation and is associated with influence on the expression of bFGF of tumor cell. 4. Salvicine has antimetastatic activity and shed new light on the complex roles of ROS and downstream signaling molecules, particularly p38 MAPK, in the regulation of integrin function and cell adhesion. | |
| BCN3164 | Sugiol |
| 1. Sugiol has antioxidant efficacy. 2. Sugiol has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals. 3. Sugiol's efficacy in inhibiting the inflammatory cytokines of IL-1beta and TNF-alpha could be attributed to a reduction of the ROS that leads to a decrease in the phosphorylation of MAPKs. | |
| BCN3166 | Mogroside IVe |
| 1. Mogroside IVe can inhibit the proliferation of HT29 and Hep-2 cells in culture and in xenografted mice in a dose-dependent manner, which is accompanied by the upregulation of tumor suppressor p53, and downregulation of matrix metallopeptidase 9 (MMP-9) and phosphorylated extracellular signal-regulated kinases (ERK)1/2. | |
| BCN3167 | Mogroside III |
| 1. The human intestinal bacteria shows potent ability to transform Mogroside III to release secondary glycoside mogroside II(A1) and aglycone mogrol. | |
